Decreased IL-2, IFN-γ, and IL-10 production by aged mice during the acute phase of E55+ retrovirus infection

Mohamed Elrefaei, Kenneth J. Blank, Donna M. Murasko

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We previously reported that aged mice demonstrated a 12-week delay in virus clearance compared to young mice after infection with E55+ murine leukemia retrovirus (E55+MuLV). The current study demonstrates that both the levels of IL-2, IFN-γ, and IL-10 and the number of cells producing IL-2 and IFN-γ were lower at 2 and 4 weeks postinfection (p.i.) in aged compared to young mice after virus-specific stimulation of spleen cells in vitro. In both age groups, IL-2 and IL-10 were produced by CD4+ T and B cells, respectively. IFN-γ was produced mainly by CD4+ T cells at 2 weeks p.i. and by CD4+ and CD8+ T cells at 4 weeks p.i. in young, but primarily by CD8+ T cells, in aged mice. Therefore, delayed virus clearance is associated with age-related decreases in type 1 and type 2 cytokines and a shift in the primary source of at least one cytokine.

Original languageEnglish (US)
Pages (from-to)8-19
Number of pages12
JournalVirology
Volume299
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Retroviridae Infections
Interleukin-10
Interleukin-2
T-Lymphocytes
Viruses
Cytokines
Retroviridae
Leukemia
B-Lymphocytes
Spleen
Age Groups
Cell Count
Infection

Keywords

  • Aging
  • B cell
  • CD4 T cell
  • CD8 T cells
  • IFN-γ
  • IL-10
  • IL-2
  • Retrovirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Decreased IL-2, IFN-γ, and IL-10 production by aged mice during the acute phase of E55+ retrovirus infection. / Elrefaei, Mohamed; Blank, Kenneth J.; Murasko, Donna M.

In: Virology, Vol. 299, No. 1, 2002, p. 8-19.

Research output: Contribution to journalArticle

Elrefaei, Mohamed ; Blank, Kenneth J. ; Murasko, Donna M. / Decreased IL-2, IFN-γ, and IL-10 production by aged mice during the acute phase of E55+ retrovirus infection. In: Virology. 2002 ; Vol. 299, No. 1. pp. 8-19.
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