Decreased IL-2, IFN-γ, and IL-10 production by aged mice during the acute phase of E55+ retrovirus infection

Mohamed Elrefaei, Kenneth J. Blank, Donna M. Murasko

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We previously reported that aged mice demonstrated a 12-week delay in virus clearance compared to young mice after infection with E55+ murine leukemia retrovirus (E55+MuLV). The current study demonstrates that both the levels of IL-2, IFN-γ, and IL-10 and the number of cells producing IL-2 and IFN-γ were lower at 2 and 4 weeks postinfection (p.i.) in aged compared to young mice after virus-specific stimulation of spleen cells in vitro. In both age groups, IL-2 and IL-10 were produced by CD4+ T and B cells, respectively. IFN-γ was produced mainly by CD4+ T cells at 2 weeks p.i. and by CD4+ and CD8+ T cells at 4 weeks p.i. in young, but primarily by CD8+ T cells, in aged mice. Therefore, delayed virus clearance is associated with age-related decreases in type 1 and type 2 cytokines and a shift in the primary source of at least one cytokine.

Original languageEnglish (US)
Pages (from-to)8-19
Number of pages12
JournalVirology
Volume299
Issue number1
DOIs
StatePublished - Jan 1 2002

Keywords

  • Aging
  • B cell
  • CD4 T cell
  • CD8 T cells
  • IFN-γ
  • IL-10
  • IL-2
  • Retrovirus

ASJC Scopus subject areas

  • Virology

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