Decreased HIV-associated T cell apoptosis by HIV protease inhibitors

Barbara N. Phenix, Jonathan B. Angel, Francis Mandy, Stephen Kravcik, Karl Parato, Kelley A. Chambers, Keith Gallicano, Nanci Hawley-Foss, Sharon Cassol, D. William Cameron, Andrew D. Badley

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Antiretroviral treatment of patients infected with HIV results in improvements in CD4+ T cell number. Emerging evidence suggests that some of the improvements-in CD4+ T cell number that occur in response to protease inhibitor (PI) therapy may not be accounted for solely by enhanced viral suppression, implying that PI may directly affect T cell survival. Since HIV T cell depletion is associated with enhanced apoptosis, we analyzed the effect of PIs on T cell apoptosis. In vitro treatment of peripheral blood lymphocytes (PBLs) from HIV-infected but untreated patients with reverse transcriptase inhibitors (RTIs) does not alter apoptosis, whereas PI treatment rapidly reduces CD4+ and CD8+ T cell apoptosis. In contrast, PI treatment does not alter apoptosis in PBL blasts from HIV-negative patients, or in Jurkat T cells. Consistent with this observation, 8 days of PI therapy in HIV-infected patients does not significantly alter plasma viremia, yet results in significant inhibition of CD4+ and CD8+ T cell apoptosis. The inhibitory effects of PI on apoptosis have implications concerning the treatment of HIV and its pathogenesis.

Original languageEnglish (US)
Pages (from-to)559-567
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume16
Issue number6
DOIs
StatePublished - Apr 10 2000

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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    Phenix, B. N., Angel, J. B., Mandy, F., Kravcik, S., Parato, K., Chambers, K. A., Gallicano, K., Hawley-Foss, N., Cassol, S., William Cameron, D., & Badley, A. D. (2000). Decreased HIV-associated T cell apoptosis by HIV protease inhibitors. AIDS Research and Human Retroviruses, 16(6), 559-567. https://doi.org/10.1089/088922200308972