TY - JOUR
T1 - Decreased circulating levels of spexin in obese children
AU - Kumar, Seema
AU - Hossain, Jobayer
AU - Nader, Nicole
AU - Aguirre, Roxana
AU - Sriram, Swetha
AU - Babu Balagopal, P.
N1 - Funding Information:
This work was supported by Mayo Clinic Center for Translational Science Activities (CTSA) Grant No. UL1 TR000135 from the National Center for Advancing Translational Sciences, a component of the National Institutes of Health (NIH).
PY - 2016/7
Y1 - 2016/7
N2 - Context: Spexin is a novel peptide that is implicated in obesity and related energy homeostasis in animals and adult humans. Little is known about its role in children. Objective: The aim of the current study was to determine the potential role of Spexin in obese children and explore its relationships with various cardiometabolic risk factors. Design and Participants: This was a cross-sectional study composed of 69 children (51 obese and 18 normal weight; age 15.3-0.26 y). Outcome Measures: Spexin was measured using a specific enzyme-linked immunosorbent assay. Leptin, total and high-molecular-weight adiponectin, IL-6, high-sensitivity C-reactive protein, glucose, and insulin were also measured. Mann-Whitney U test, Pearson and Spearman rank correlations, logistic regression, and cluster analysis were used for the analysis and interpretation of the data. Results: Spexin levels were significantly lower in obese vs normal-weight children, median(IQR) (0.33 ng/mL [0.27-0.44] vs 0.42 ng/mL [0.33-0.55]; P <.024), but did not correlate with other adipokines and/or insulin and glucose levels. Ordinal categorical variables of Spexin showed a strictly reverse association of obesity with the level of Spexin. Cluster analysis of Spexin and body mass index z score resulted in splitting the participants into normal-weight and obese-weight groups with high accuracy. Conclusions: Lower circulating levels of Spexin in obese children compared with their normalweight counterparts and the ability to discriminate obese and normal-weight groups based on Spexin concentration enabled us to suggest a potential role for this novel peptide in childhood obesity. The clinical significance of these findings needs additional investigation.
AB - Context: Spexin is a novel peptide that is implicated in obesity and related energy homeostasis in animals and adult humans. Little is known about its role in children. Objective: The aim of the current study was to determine the potential role of Spexin in obese children and explore its relationships with various cardiometabolic risk factors. Design and Participants: This was a cross-sectional study composed of 69 children (51 obese and 18 normal weight; age 15.3-0.26 y). Outcome Measures: Spexin was measured using a specific enzyme-linked immunosorbent assay. Leptin, total and high-molecular-weight adiponectin, IL-6, high-sensitivity C-reactive protein, glucose, and insulin were also measured. Mann-Whitney U test, Pearson and Spearman rank correlations, logistic regression, and cluster analysis were used for the analysis and interpretation of the data. Results: Spexin levels were significantly lower in obese vs normal-weight children, median(IQR) (0.33 ng/mL [0.27-0.44] vs 0.42 ng/mL [0.33-0.55]; P <.024), but did not correlate with other adipokines and/or insulin and glucose levels. Ordinal categorical variables of Spexin showed a strictly reverse association of obesity with the level of Spexin. Cluster analysis of Spexin and body mass index z score resulted in splitting the participants into normal-weight and obese-weight groups with high accuracy. Conclusions: Lower circulating levels of Spexin in obese children compared with their normalweight counterparts and the ability to discriminate obese and normal-weight groups based on Spexin concentration enabled us to suggest a potential role for this novel peptide in childhood obesity. The clinical significance of these findings needs additional investigation.
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U2 - 10.1210/jc.2016-1177
DO - 10.1210/jc.2016-1177
M3 - Article
C2 - 27218269
AN - SCOPUS:84978401138
VL - 101
SP - 2931
EP - 2936
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 7
ER -