Decreased catecholamine content in parkinsonian adrenal medullae

Susan L. Stoddard, Gertrude M. Tyce, J. Eric Ahlskog, Alan R. Zinsmeister, Stephen W. Carmichael

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Autopsy specimens of adrenal medullae from parkinsonian and nonparkinsonian patients were analyzed for free catecholamines by high-performance liquid chromatography with electrochemical detection. The total free catecholamine content (nanomoles free catecholamine per milligram protein) was significantly lower in the parkinsonian patients than in the control population when the values were corrected for age and time from death to organ harvest. It is not established whether this decreased catecholamine content in the adrenals of parkinsonian patients is a concomitant of the disease itself or whether it is secondary to drug therapies used to treat the symptoms of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalExperimental Neurology
Volume104
Issue number1
DOIs
StatePublished - Apr 1989

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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    Stoddard, S. L., Tyce, G. M., Eric Ahlskog, J., Zinsmeister, A. R., & Carmichael, S. W. (1989). Decreased catecholamine content in parkinsonian adrenal medullae. Experimental Neurology, 104(1), 22-27. https://doi.org/10.1016/0014-4886(89)90004-6