Decreased catecholamine content in parkinsonian adrenal medullae

Susan L. Stoddard; Gertrude M. Tyce; J. Eric Ahlskog; Alan R. Zinsmeister; Stephen W. Carmichael

doi:10.1016/0014-4886(89)90004-6

Decreased catecholamine content in parkinsonian adrenal medullae

Susan L. Stoddard, Gertrude M. Tyce, J. Eric Ahlskog, Alan R. Zinsmeister, Stephen W. Carmichael

Quantitative Health Sciences

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Abstract

Autopsy specimens of adrenal medullae from parkinsonian and nonparkinsonian patients were analyzed for free catecholamines by high-performance liquid chromatography with electrochemical detection. The total free catecholamine content (nanomoles free catecholamine per milligram protein) was significantly lower in the parkinsonian patients than in the control population when the values were corrected for age and time from death to organ harvest. It is not established whether this decreased catecholamine content in the adrenals of parkinsonian patients is a concomitant of the disease itself or whether it is secondary to drug therapies used to treat the symptoms of Parkinson's disease.

Original language	English (US)
Pages (from-to)	22-27
Number of pages	6
Journal	Experimental Neurology
Volume	104
Issue number	1
DOIs	https://doi.org/10.1016/0014-4886(89)90004-6
State	Published - Apr 1989

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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@article{fb991536de954832b1fd4ee21c38500c,

title = "Decreased catecholamine content in parkinsonian adrenal medullae",

abstract = "Autopsy specimens of adrenal medullae from parkinsonian and nonparkinsonian patients were analyzed for free catecholamines by high-performance liquid chromatography with electrochemical detection. The total free catecholamine content (nanomoles free catecholamine per milligram protein) was significantly lower in the parkinsonian patients than in the control population when the values were corrected for age and time from death to organ harvest. It is not established whether this decreased catecholamine content in the adrenals of parkinsonian patients is a concomitant of the disease itself or whether it is secondary to drug therapies used to treat the symptoms of Parkinson's disease.",

author = "Stoddard, {Susan L.} and Tyce, {Gertrude M.} and {Eric Ahlskog}, J. and Zinsmeister, {Alan R.} and Carmichael, {Stephen W.}",

note = "Funding Information: The authors thank Dr. H. Okazaki for neuropathological examinations, Mr. Robert Wilson for technical assistance, Ms. Sharon Chin-now for performing the catecholamine assays, Ms. Pam Hammond for the protein determinations, and Ms. Eva Gankiewicz and Ms. Julie Kettelkamp for preparation of the graphs. The comments of Drs. W. S. Brimijoin and L. J. Melton III throughout this project are appreciated. This work was supported, in part, by grants from the United Parkinson Disease Foundation (S.W.C.) and by NS 17858 (G.M.T.).",

year = "1989",

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doi = "10.1016/0014-4886(89)90004-6",

language = "English (US)",

volume = "104",

pages = "22--27",

journal = "Experimental Neurology",

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T1 - Decreased catecholamine content in parkinsonian adrenal medullae

AU - Stoddard, Susan L.

AU - Tyce, Gertrude M.

AU - Eric Ahlskog, J.

AU - Zinsmeister, Alan R.

AU - Carmichael, Stephen W.

N1 - Funding Information: The authors thank Dr. H. Okazaki for neuropathological examinations, Mr. Robert Wilson for technical assistance, Ms. Sharon Chin-now for performing the catecholamine assays, Ms. Pam Hammond for the protein determinations, and Ms. Eva Gankiewicz and Ms. Julie Kettelkamp for preparation of the graphs. The comments of Drs. W. S. Brimijoin and L. J. Melton III throughout this project are appreciated. This work was supported, in part, by grants from the United Parkinson Disease Foundation (S.W.C.) and by NS 17858 (G.M.T.).

PY - 1989/4

Y1 - 1989/4

N2 - Autopsy specimens of adrenal medullae from parkinsonian and nonparkinsonian patients were analyzed for free catecholamines by high-performance liquid chromatography with electrochemical detection. The total free catecholamine content (nanomoles free catecholamine per milligram protein) was significantly lower in the parkinsonian patients than in the control population when the values were corrected for age and time from death to organ harvest. It is not established whether this decreased catecholamine content in the adrenals of parkinsonian patients is a concomitant of the disease itself or whether it is secondary to drug therapies used to treat the symptoms of Parkinson's disease.

AB - Autopsy specimens of adrenal medullae from parkinsonian and nonparkinsonian patients were analyzed for free catecholamines by high-performance liquid chromatography with electrochemical detection. The total free catecholamine content (nanomoles free catecholamine per milligram protein) was significantly lower in the parkinsonian patients than in the control population when the values were corrected for age and time from death to organ harvest. It is not established whether this decreased catecholamine content in the adrenals of parkinsonian patients is a concomitant of the disease itself or whether it is secondary to drug therapies used to treat the symptoms of Parkinson's disease.

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Decreased catecholamine content in parkinsonian adrenal medullae

Abstract

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