Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients

Susan L. Stoddard, J. Eric Ahlskog, Patrick J. Kelly, Gertrude M. Tyce, Jon A. van Heerden, Alan R. Zinsmeister, Stephen W. Carmichael

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Adrenal medullary catecholamines were measured in tissue samples from eight patients who underwent autologous transplantation of the adrenal medulla to the caudate nucleus as a treatment for Parkinson's disease. These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalExperimental Neurology
Volume104
Issue number3
DOIs
StatePublished - Jun 1989

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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    Stoddard, S. L., Ahlskog, J. E., Kelly, P. J., Tyce, G. M., van Heerden, J. A., Zinsmeister, A. R., & Carmichael, S. W. (1989). Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients. Experimental Neurology, 104(3), 218-222. https://doi.org/10.1016/0014-4886(89)90032-0