Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients

Susan L. Stoddard, J. Eric Ahlskog, Patrick J. Kelly, Gertrude M. Tyce, Jon A. van Heerden, Alan R. Zinsmeister, Stephen W. Carmichael

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Adrenal medullary catecholamines were measured in tissue samples from eight patients who underwent autologous transplantation of the adrenal medulla to the caudate nucleus as a treatment for Parkinson's disease. These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalExperimental Neurology
Volume104
Issue number3
DOIs
StatePublished - 1989

Fingerprint

Nephrectomy
Catecholamines
Adrenal Medulla
Autologous Transplantation
Caudate Nucleus
Renal Cell Carcinoma
Parkinson Disease
Autopsy
Dopamine
Transplantation
Weights and Measures
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Stoddard, S. L., Ahlskog, J. E., Kelly, P. J., Tyce, G. M., van Heerden, J. A., Zinsmeister, A. R., & Carmichael, S. W. (1989). Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients. Experimental Neurology, 104(3), 218-222. https://doi.org/10.1016/0014-4886(89)90032-0

Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients. / Stoddard, Susan L.; Ahlskog, J. Eric; Kelly, Patrick J.; Tyce, Gertrude M.; van Heerden, Jon A.; Zinsmeister, Alan R.; Carmichael, Stephen W.

In: Experimental Neurology, Vol. 104, No. 3, 1989, p. 218-222.

Research output: Contribution to journalArticle

Stoddard, SL, Ahlskog, JE, Kelly, PJ, Tyce, GM, van Heerden, JA, Zinsmeister, AR & Carmichael, SW 1989, 'Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients', Experimental Neurology, vol. 104, no. 3, pp. 218-222. https://doi.org/10.1016/0014-4886(89)90032-0
Stoddard, Susan L. ; Ahlskog, J. Eric ; Kelly, Patrick J. ; Tyce, Gertrude M. ; van Heerden, Jon A. ; Zinsmeister, Alan R. ; Carmichael, Stephen W. / Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients. In: Experimental Neurology. 1989 ; Vol. 104, No. 3. pp. 218-222.
@article{4eddc6ca59ce46cabcfc133d994b76e5,
title = "Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients",
abstract = "Adrenal medullary catecholamines were measured in tissue samples from eight patients who underwent autologous transplantation of the adrenal medulla to the caudate nucleus as a treatment for Parkinson's disease. These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.",
author = "Stoddard, {Susan L.} and Ahlskog, {J. Eric} and Kelly, {Patrick J.} and Tyce, {Gertrude M.} and {van Heerden}, {Jon A.} and Zinsmeister, {Alan R.} and Carmichael, {Stephen W.}",
year = "1989",
doi = "10.1016/0014-4886(89)90032-0",
language = "English (US)",
volume = "104",
pages = "218--222",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients

AU - Stoddard, Susan L.

AU - Ahlskog, J. Eric

AU - Kelly, Patrick J.

AU - Tyce, Gertrude M.

AU - van Heerden, Jon A.

AU - Zinsmeister, Alan R.

AU - Carmichael, Stephen W.

PY - 1989

Y1 - 1989

N2 - Adrenal medullary catecholamines were measured in tissue samples from eight patients who underwent autologous transplantation of the adrenal medulla to the caudate nucleus as a treatment for Parkinson's disease. These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.

AB - Adrenal medullary catecholamines were measured in tissue samples from eight patients who underwent autologous transplantation of the adrenal medulla to the caudate nucleus as a treatment for Parkinson's disease. These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.

UR - http://www.scopus.com/inward/record.url?scp=0024397287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024397287&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(89)90032-0

DO - 10.1016/0014-4886(89)90032-0

M3 - Article

C2 - 2721624

AN - SCOPUS:0024397287

VL - 104

SP - 218

EP - 222

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 3

ER -