Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients

Susan L. Stoddard; J. Eric Ahlskog; Patrick J. Kelly; Gertrude M. Tyce; Jon A. van Heerden; Alan R. Zinsmeister; Stephen W. Carmichael

doi:10.1016/0014-4886(89)90032-0

Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients

Susan L. Stoddard, J. Eric Ahlskog, Patrick J. Kelly, Gertrude M. Tyce, Jon A. van Heerden, Alan R. Zinsmeister, Stephen W. Carmichael

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Adrenal medullary catecholamines were measured in tissue samples from eight patients who underwent autologous transplantation of the adrenal medulla to the caudate nucleus as a treatment for Parkinson's disease. These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.

Original language	English (US)
Pages (from-to)	218-222
Number of pages	5
Journal	Experimental Neurology
Volume	104
Issue number	3
DOIs	https://doi.org/10.1016/0014-4886(89)90032-0
State	Published - Jun 1989

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

Access to Document

10.1016/0014-4886(89)90032-0

Cite this

@article{4eddc6ca59ce46cabcfc133d994b76e5,

title = "Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients",

abstract = "Adrenal medullary catecholamines were measured in tissue samples from eight patients who underwent autologous transplantation of the adrenal medulla to the caudate nucleus as a treatment for Parkinson's disease. These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.",

author = "Stoddard, {Susan L.} and Ahlskog, {J. Eric} and Kelly, {Patrick J.} and Tyce, {Gertrude M.} and {van Heerden}, {Jon A.} and Zinsmeister, {Alan R.} and Carmichael, {Stephen W.}",

note = "Funding Information: The authors thank Don Engen, M.D., the staff of the Urology Department, Mayo Clinic, and Dianne Fitch, Surgical Pathology Laboratory, Rochester Methodist Hospital, for their assistance in providing tissue from nephrectomy patients. The technical expertise of Mr. Robert Wilson and Ms. Sharon Chinnow in performing the catecholamine assays is appreciated. We also thank Mr. Stewart Chritton for his assistance. This work was supported, in part, by grants from the United Parkinson Foundation (S.W.C.) and NS 17858 (G.M.T.).",

year = "1989",

month = jun,

doi = "10.1016/0014-4886(89)90032-0",

language = "English (US)",

volume = "104",

pages = "218--222",

journal = "Experimental Neurology",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients

AU - Stoddard, Susan L.

AU - Ahlskog, J. Eric

AU - Kelly, Patrick J.

AU - Tyce, Gertrude M.

AU - van Heerden, Jon A.

AU - Zinsmeister, Alan R.

AU - Carmichael, Stephen W.

N1 - Funding Information: The authors thank Don Engen, M.D., the staff of the Urology Department, Mayo Clinic, and Dianne Fitch, Surgical Pathology Laboratory, Rochester Methodist Hospital, for their assistance in providing tissue from nephrectomy patients. The technical expertise of Mr. Robert Wilson and Ms. Sharon Chinnow in performing the catecholamine assays is appreciated. We also thank Mr. Stewart Chritton for his assistance. This work was supported, in part, by grants from the United Parkinson Foundation (S.W.C.) and NS 17858 (G.M.T.).

PY - 1989/6

Y1 - 1989/6

N2 - Adrenal medullary catecholamines were measured in tissue samples from eight patients who underwent autologous transplantation of the adrenal medulla to the caudate nucleus as a treatment for Parkinson's disease. These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.

AB - Adrenal medullary catecholamines were measured in tissue samples from eight patients who underwent autologous transplantation of the adrenal medulla to the caudate nucleus as a treatment for Parkinson's disease. These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.

UR - http://www.scopus.com/inward/record.url?scp=0024397287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024397287&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(89)90032-0

DO - 10.1016/0014-4886(89)90032-0

M3 - Article

C2 - 2721624

AN - SCOPUS:0024397287

SN - 0014-4886

VL - 104

SP - 218

EP - 222

JO - Experimental Neurology

JF - Experimental Neurology

IS - 3

ER -

Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this