Declines in switching underlie verbal fluency changes after unilateral pallidal surgery in Parkinson's disease

Alexander I. Tröster, Steven Paul Woods, Julie A. Fields, Charlotte Hanisch, William W. Beatty

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Declines in verbal fluency are consistently reported in patients with Parkinson's disease (PD) after pallidal surgery. In the present study, the clustering and switching components of semantic or category fluency (oral naming of items obtainable in supermarkets) were examined at baseline and four months after unilateral deep brain stimulation or pallidotomy in 45 patients with PD (30 left, 15 right pallidal surgery). Post-operative declines were observed for supermarket fluency total score and switching, but not for average cluster size. These findings support the proposal that semantic fluency decrements after pallidal surgery reflect a disruption of frontal-basal ganglia circuits mediating efficient shifting between semantic categories, or perhaps efficient access to categories, rather than a degradation of semantic stores.

Original languageEnglish (US)
Pages (from-to)207-217
Number of pages11
JournalBrain and Cognition
Volume50
Issue number2
DOIs
StatePublished - Dec 1 2002

Keywords

  • Deep brain stimulation
  • Globus pallidus
  • Pallidotomy
  • Parkinson's disease
  • Verbal fluency

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

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