TY - JOUR
T1 - Decline in bilateral orchiectomy for prostate cancer in Olmsted County, Minnesota, 1956-2000
AU - Melton, L. Joseph
AU - Alothman, Khalid I.
AU - Achenbach, Sara J.
AU - Ofallon, W. Michael
AU - Zincke, Horst
N1 - Funding Information:
This work was supported in part by research grants AG04875 and AR30582 from the National Institutes of Health, US Public Health Service .
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Objective: To assess long-term secular trends in the utilization of bilateral compared with unilateral orchiectomy in the community. Patients and Methods: This population-based descriptive study reviewed medical records of all Olmsted County, Minnesota, men undergoing orchiectomy between 1956 and 2000. Results: Over the 45-year study period, 381 Olmsted County men had a first unilateral orchiectomy, while 431 underwent bilateral orchiectomy (including 8 with a second unilateral orchiectomy). There was no change over time in the age-adjusted utilization of unilateral orchiectomy, which was performed for a wide range of indications, mostly cryptorchidism and testicular malignancy. Most bilateral procedures, on the other hand, were in elderly men for castration, and trends over time generally paralleled those reported for prostate cancer in this community. Conclusion: The declining incidence of prostate cancer in recent years, combined with a shift to earlier stages and younger ages at diagnosis, and the development of pharmacological approaches to hormonal manipulation have led to a dramatic decline in the utilization of bilateral orchiectomy, while unilateral orchiectomy rates have remained unchanged.
AB - Objective: To assess long-term secular trends in the utilization of bilateral compared with unilateral orchiectomy in the community. Patients and Methods: This population-based descriptive study reviewed medical records of all Olmsted County, Minnesota, men undergoing orchiectomy between 1956 and 2000. Results: Over the 45-year study period, 381 Olmsted County men had a first unilateral orchiectomy, while 431 underwent bilateral orchiectomy (including 8 with a second unilateral orchiectomy). There was no change over time in the age-adjusted utilization of unilateral orchiectomy, which was performed for a wide range of indications, mostly cryptorchidism and testicular malignancy. Most bilateral procedures, on the other hand, were in elderly men for castration, and trends over time generally paralleled those reported for prostate cancer in this community. Conclusion: The declining incidence of prostate cancer in recent years, combined with a shift to earlier stages and younger ages at diagnosis, and the development of pharmacological approaches to hormonal manipulation have led to a dramatic decline in the utilization of bilateral orchiectomy, while unilateral orchiectomy rates have remained unchanged.
KW - CI = confidence interval
KW - DES = diethylstilbestrol
KW - LHRH = luteinizing hormone-releasing hormone
KW - PSA = prostate-specific antigen
UR - http://www.scopus.com/inward/record.url?scp=0035208717&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035208717&partnerID=8YFLogxK
U2 - 10.4065/76.12.1199
DO - 10.4065/76.12.1199
M3 - Article
C2 - 11761500
AN - SCOPUS:0035208717
SN - 0025-6196
VL - 76
SP - 1199
EP - 1203
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 12
ER -