TY - JOUR
T1 - Decitabine for acute myeloid leukemia in a patient undergoing hemodialysis
AU - Kourelis, Taxiarchis V.
AU - Moustakakis, M. N.
AU - Silk, R.
AU - Pharm, D.
AU - Boruchov, A.
AU - Bilgrami, S. F.
PY - 2011
Y1 - 2011
N2 - Treatment of patients with Acute Myeloid Leukemia (AML) undergoing hemodialysis is especially challenging since there are no specific management guidelines for the administration of cytotoxic agents in these patients. Well established chemotherapy protocols may be unsuitable in such cases because of altered drug pharmacokinetics, increased risk for complications, and underlying co-morbidities. In addition, these patients are at an increased risk for complications such as tumor lysis syndrome. Herein, we report the first use of decitabine in a patient on hemodialysis. He presented with a new diagnosis of AML and achieved hematologic remission following the use of induction chemotherapy and maintenance decitabine.
AB - Treatment of patients with Acute Myeloid Leukemia (AML) undergoing hemodialysis is especially challenging since there are no specific management guidelines for the administration of cytotoxic agents in these patients. Well established chemotherapy protocols may be unsuitable in such cases because of altered drug pharmacokinetics, increased risk for complications, and underlying co-morbidities. In addition, these patients are at an increased risk for complications such as tumor lysis syndrome. Herein, we report the first use of decitabine in a patient on hemodialysis. He presented with a new diagnosis of AML and achieved hematologic remission following the use of induction chemotherapy and maintenance decitabine.
KW - Acute myeloid leukemia
KW - Decitabine
KW - Hemodialysis
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U2 - 10.1177/1721727X1100900310
DO - 10.1177/1721727X1100900310
M3 - Article
AN - SCOPUS:84858629916
SN - 1721-727X
VL - 9
SP - 289
EP - 292
JO - European Journal of Inflammation
JF - European Journal of Inflammation
IS - 3
ER -