Death receptor-mediated liver injury

Yuko Akazawa, Gregory James Gores

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Apoptosis is a cardinal feature of liver injury. Death receptors are major mediators of the apoptotic pathway in the liver and have been implicated in the pathogenesis of diverse human diseases. More importantly, several studies have demonstrated a link between apoptosis and hepatic fibrosis; the latter is the most ominous consequence of chronic liver injury. In this article, we focus on the four death receptors: Fas, tumor necrosis factor receptor 1, tumor necrosis factor-related apoptosis-inducing ligand receptor 1, and tumor necrosis factor-related apoptosis-inducing ligand receptor 2. Although the death receptors have similar structures, they also possess distinct characteristics in their signaling pathways. Fas is abundantly expressed by all cells in the liver and plays a central role in variety of liver diseases. Tumor necrosis factor receptor 1 can induce both proapoptotic and prosurvival pathways. Tumor necrosis factor-related apoptosis-inducing ligand receptors likely trigger selective cell death in malignant and viral infected cells. Understanding the mechanism of liver injury caused by death receptors will enable therapeutic strategies to ameliorate human liver diseases.

Original languageEnglish (US)
Pages (from-to)327-338
Number of pages12
JournalSeminars in Liver Disease
Volume27
Issue number4
DOIs
StatePublished - Nov 2007

Fingerprint

Death Domain Receptors
Apoptosis
Tumor Necrosis Factor Receptors
Liver
Wounds and Injuries
Ligands
Liver Diseases
Tumor Necrosis Factor-alpha
Fibrosis
Cell Death

Keywords

  • Caspase inhibition
  • Fibrosis
  • Lipoapotosis

ASJC Scopus subject areas

  • Hepatology

Cite this

Death receptor-mediated liver injury. / Akazawa, Yuko; Gores, Gregory James.

In: Seminars in Liver Disease, Vol. 27, No. 4, 11.2007, p. 327-338.

Research output: Contribution to journalArticle

Akazawa, Yuko ; Gores, Gregory James. / Death receptor-mediated liver injury. In: Seminars in Liver Disease. 2007 ; Vol. 27, No. 4. pp. 327-338.
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