Death analysis of childhood acute lymphoblastic leukaemia; experience at shaukat khanum memorial cancer hospital and research centre, pakistan

Muhammad Asim, Alia Zaidi, Tariq Ghafoor, Muhammad Yasir Qureshi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives: To analyze the common causes of death in childhood Acute Lymphoblastic Leukaemia (ALL) patients during therapy at Paediatric Oncology Department of Shaukat Khanum Memorial Cancer Hospital. Methods: Retrospective descriptive study conducted at Paediatric Oncology department at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore Pakistan. All registered cases of ALL from 12 months to 18 years of age who expired between May 2001 to December 2005 were included. Mortality data was collected and analyzed regarding age, sex, WBC count, immunophenotype, treatment protocol, remission, and timing of death with respect to treatment protocol and the cause of death. Results: Out of 304 new cases of ALL registered in the study period, 74 (24%) died during treatment. During induction 39 of 74 (52.7%) died, 33 (44.5%) in first remission and 2 (2.8%) before initiation of therapy. Infection alone or in combination with other factors was responsible for deaths in 63 of 74 (85%) cases. Septicemia, pulmonary and gastrointestinal infections were documented in 37/63 (58.7%), 44/63 (69%) and 8/63 (12.6%) cases respectively. Eight (10.8%) died due to haemorrhage. Three (4%) deaths were secondary to chemotherapy induced toxicity. Conclusion: Infection is the major cause of mortality in ALL patients in our study population. To improve survival it is imperative to improve supportive care especially prevention and management of infection.

Original languageEnglish (US)
Pages (from-to)666-670
Number of pages5
JournalJPMA. The Journal of the Pakistan Medical Association
Volume61
Issue number7
StatePublished - Jul 2011
Externally publishedYes

Fingerprint

Cancer Care Facilities
Pakistan
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinical Protocols
Infection
Research
Cause of Death
Pediatrics
Mortality
Sepsis
Therapeutics
Retrospective Studies
Hemorrhage
Drug Therapy
Lung
Survival
Population

Keywords

  • Acute Lymphoblastic Leukaemia
  • Developing countries
  • Infection
  • Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Death analysis of childhood acute lymphoblastic leukaemia; experience at shaukat khanum memorial cancer hospital and research centre, pakistan",
abstract = "Objectives: To analyze the common causes of death in childhood Acute Lymphoblastic Leukaemia (ALL) patients during therapy at Paediatric Oncology Department of Shaukat Khanum Memorial Cancer Hospital. Methods: Retrospective descriptive study conducted at Paediatric Oncology department at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore Pakistan. All registered cases of ALL from 12 months to 18 years of age who expired between May 2001 to December 2005 were included. Mortality data was collected and analyzed regarding age, sex, WBC count, immunophenotype, treatment protocol, remission, and timing of death with respect to treatment protocol and the cause of death. Results: Out of 304 new cases of ALL registered in the study period, 74 (24{\%}) died during treatment. During induction 39 of 74 (52.7{\%}) died, 33 (44.5{\%}) in first remission and 2 (2.8{\%}) before initiation of therapy. Infection alone or in combination with other factors was responsible for deaths in 63 of 74 (85{\%}) cases. Septicemia, pulmonary and gastrointestinal infections were documented in 37/63 (58.7{\%}), 44/63 (69{\%}) and 8/63 (12.6{\%}) cases respectively. Eight (10.8{\%}) died due to haemorrhage. Three (4{\%}) deaths were secondary to chemotherapy induced toxicity. Conclusion: Infection is the major cause of mortality in ALL patients in our study population. To improve survival it is imperative to improve supportive care especially prevention and management of infection.",
keywords = "Acute Lymphoblastic Leukaemia, Developing countries, Infection, Mortality",
author = "Muhammad Asim and Alia Zaidi and Tariq Ghafoor and Qureshi, {Muhammad Yasir}",
year = "2011",
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language = "English (US)",
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pages = "666--670",
journal = "JPMA. The Journal of the Pakistan Medical Association",
issn = "0030-9982",
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T1 - Death analysis of childhood acute lymphoblastic leukaemia; experience at shaukat khanum memorial cancer hospital and research centre, pakistan

AU - Asim, Muhammad

AU - Zaidi, Alia

AU - Ghafoor, Tariq

AU - Qureshi, Muhammad Yasir

PY - 2011/7

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N2 - Objectives: To analyze the common causes of death in childhood Acute Lymphoblastic Leukaemia (ALL) patients during therapy at Paediatric Oncology Department of Shaukat Khanum Memorial Cancer Hospital. Methods: Retrospective descriptive study conducted at Paediatric Oncology department at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore Pakistan. All registered cases of ALL from 12 months to 18 years of age who expired between May 2001 to December 2005 were included. Mortality data was collected and analyzed regarding age, sex, WBC count, immunophenotype, treatment protocol, remission, and timing of death with respect to treatment protocol and the cause of death. Results: Out of 304 new cases of ALL registered in the study period, 74 (24%) died during treatment. During induction 39 of 74 (52.7%) died, 33 (44.5%) in first remission and 2 (2.8%) before initiation of therapy. Infection alone or in combination with other factors was responsible for deaths in 63 of 74 (85%) cases. Septicemia, pulmonary and gastrointestinal infections were documented in 37/63 (58.7%), 44/63 (69%) and 8/63 (12.6%) cases respectively. Eight (10.8%) died due to haemorrhage. Three (4%) deaths were secondary to chemotherapy induced toxicity. Conclusion: Infection is the major cause of mortality in ALL patients in our study population. To improve survival it is imperative to improve supportive care especially prevention and management of infection.

AB - Objectives: To analyze the common causes of death in childhood Acute Lymphoblastic Leukaemia (ALL) patients during therapy at Paediatric Oncology Department of Shaukat Khanum Memorial Cancer Hospital. Methods: Retrospective descriptive study conducted at Paediatric Oncology department at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore Pakistan. All registered cases of ALL from 12 months to 18 years of age who expired between May 2001 to December 2005 were included. Mortality data was collected and analyzed regarding age, sex, WBC count, immunophenotype, treatment protocol, remission, and timing of death with respect to treatment protocol and the cause of death. Results: Out of 304 new cases of ALL registered in the study period, 74 (24%) died during treatment. During induction 39 of 74 (52.7%) died, 33 (44.5%) in first remission and 2 (2.8%) before initiation of therapy. Infection alone or in combination with other factors was responsible for deaths in 63 of 74 (85%) cases. Septicemia, pulmonary and gastrointestinal infections were documented in 37/63 (58.7%), 44/63 (69%) and 8/63 (12.6%) cases respectively. Eight (10.8%) died due to haemorrhage. Three (4%) deaths were secondary to chemotherapy induced toxicity. Conclusion: Infection is the major cause of mortality in ALL patients in our study population. To improve survival it is imperative to improve supportive care especially prevention and management of infection.

KW - Acute Lymphoblastic Leukaemia

KW - Developing countries

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