De novo hypertension after liver transplantation

Stephen C Textor, G. F. DiBona, C. Thomas, A. Fitz, C. Pruchno, W. Lawton, J. A. Bertolatus, L. Tobacman

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone. The pathogenesis appears to be multifactorial but involves rapidly rising vasoconstrictor tone in renal and systemic vascular beds. Much of this tone reflects abnormal vascular function, characterized by impaired prostacyclin and EDRF effects, in conjunction with increased vasoconstriction due to endothelin and possibly other factors. Effective management of the transplant recipient depends on preventing excessive vasoconstriction, usually with calcium channel blocking agents.

Original languageEnglish (US)
Pages (from-to)257-267
Number of pages11
JournalHypertension
Volume22
Issue number2
StatePublished - 1993

Fingerprint

Vasoconstriction
Liver Transplantation
Blood Vessels
Hypertension
Endothelins
Vasoconstrictor Agents
Epoprostenol
Calcium Channels
Prednisone
Immunosuppression
Cyclosporine
Transplantation
Kidney
Transplant Recipients

Keywords

  • cyclosporine
  • endothelins
  • hypertension, posttransplant
  • kidney
  • liver transplantation
  • prostaglandins
  • renal circulation

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Textor, S. C., DiBona, G. F., Thomas, C., Fitz, A., Pruchno, C., Lawton, W., ... Tobacman, L. (1993). De novo hypertension after liver transplantation. Hypertension, 22(2), 257-267.

De novo hypertension after liver transplantation. / Textor, Stephen C; DiBona, G. F.; Thomas, C.; Fitz, A.; Pruchno, C.; Lawton, W.; Bertolatus, J. A.; Tobacman, L.

In: Hypertension, Vol. 22, No. 2, 1993, p. 257-267.

Research output: Contribution to journalArticle

Textor, SC, DiBona, GF, Thomas, C, Fitz, A, Pruchno, C, Lawton, W, Bertolatus, JA & Tobacman, L 1993, 'De novo hypertension after liver transplantation', Hypertension, vol. 22, no. 2, pp. 257-267.
Textor SC, DiBona GF, Thomas C, Fitz A, Pruchno C, Lawton W et al. De novo hypertension after liver transplantation. Hypertension. 1993;22(2):257-267.
Textor, Stephen C ; DiBona, G. F. ; Thomas, C. ; Fitz, A. ; Pruchno, C. ; Lawton, W. ; Bertolatus, J. A. ; Tobacman, L. / De novo hypertension after liver transplantation. In: Hypertension. 1993 ; Vol. 22, No. 2. pp. 257-267.
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