De novo focal glomerulosclerosis after kidney transplantation

Anthony C. Woolley, Mark E. Rosenberg, Barbara A. Burke, Karl A Nath

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A transplanted kidney in a patient developed focal and segmental glomerulosclerosis, associated with severe systemic hypertension, proteinuria, progressive azotemia, and allograft hypertrophy. A pediatric kidney with two main arteries was used, and occlusion of the artery supplying the upper pole resulted in infarction of this portion of the allograft. Because other known factors predisposing to focal sclerosis were absent, it is postulated that renal hemodynamic changes associated with reduction in functioning renal mass, attended by striking stimuli for renal hypertrophy, resulted in progressive damage. The implications of these concepts are discussed in relation to the progression of renal diseases.

Original languageEnglish (US)
Pages (from-to)310-314
Number of pages5
JournalThe American journal of medicine
Volume84
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Focal Segmental Glomerulosclerosis
Kidney Transplantation
Kidney
Hypertrophy
Allografts
Arteries
Azotemia
Sclerosis
Proteinuria
Causality
Infarction
Disease Progression
Hemodynamics
Pediatrics
Hypertension

ASJC Scopus subject areas

  • Nursing(all)

Cite this

De novo focal glomerulosclerosis after kidney transplantation. / Woolley, Anthony C.; Rosenberg, Mark E.; Burke, Barbara A.; Nath, Karl A.

In: The American journal of medicine, Vol. 84, No. 2, 1988, p. 310-314.

Research output: Contribution to journalArticle

Woolley, Anthony C. ; Rosenberg, Mark E. ; Burke, Barbara A. ; Nath, Karl A. / De novo focal glomerulosclerosis after kidney transplantation. In: The American journal of medicine. 1988 ; Vol. 84, No. 2. pp. 310-314.
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