DCCT and EDIC studies in type 1 diabetes: Lessons for diabetic neuropathy regarding metabolic memory and natural history

Rodica Pop-Busui, William H. Herman, Eva L. Feldman, Phillip A. Low, Catherine L. Martin, Patricia A. Cleary, Barbara H. Waberski, John M. Lachin, James W. Albers

Research output: Contribution to journalReview article

81 Scopus citations

Abstract

The DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications) provides a comprehensive characterization of the natural history of diabetic neuropathy in patients with type 1 diabetes and provides insight into the impact of intensive insulin therapy in disease progression. The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review.

Original languageEnglish (US)
Pages (from-to)276-282
Number of pages7
JournalCurrent diabetes reports
Volume10
Issue number4
DOIs
StatePublished - Aug 2010

Keywords

  • Cardiovascular autonomic neuropathy
  • Distal symmetrical polyneuropathy
  • Glycemic control
  • Heart rate variability studies
  • Nerve conduction studies

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Pop-Busui, R., Herman, W. H., Feldman, E. L., Low, P. A., Martin, C. L., Cleary, P. A., Waberski, B. H., Lachin, J. M., & Albers, J. W. (2010). DCCT and EDIC studies in type 1 diabetes: Lessons for diabetic neuropathy regarding metabolic memory and natural history. Current diabetes reports, 10(4), 276-282. https://doi.org/10.1007/s11892-010-0120-8