@article{46a4bf54e9ce4c3abe68d9a8602a7aec,
title = "DCCT and EDIC studies in type 1 diabetes: Lessons for diabetic neuropathy regarding metabolic memory and natural history",
abstract = "The DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications) provides a comprehensive characterization of the natural history of diabetic neuropathy in patients with type 1 diabetes and provides insight into the impact of intensive insulin therapy in disease progression. The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review.",
keywords = "Cardiovascular autonomic neuropathy, Distal symmetrical polyneuropathy, Glycemic control, Heart rate variability studies, Nerve conduction studies",
author = "Rodica Pop-Busui and Herman, {William H.} and Feldman, {Eva L.} and Low, {Phillip A.} and Martin, {Catherine L.} and Cleary, {Patricia A.} and Waberski, {Barbara H.} and Lachin, {John M.} and Albers, {James W.}",
note = "Funding Information: Disclosure The DCCT/EDIC project is supported by contracts with the Division of Diabetes, Endocrinology and Metabolic Diseases of the National Institute of Diabetes and Digestive and Kidney Diseases, National Eye Institute, National Institute of Neurological Disorders and Stroke, the General Clinical Research Centers Program and the Clinical and Translational Science Awards Program, National Center for Research Resources, and by Genentech through a Cooperative Research and Development Agreement with the National Institute of Diabetes and Digestive and Kidney Diseases. Funding Information: Dr. Rodica Pop-Busui is also supported by the American Diabetes Association Grant 1-08-CR-48, the Juvenile Diabetes Research Foundation Grant 1-2008-1025, and the Juvenile Diabetes Research Foundation for the Study of Complications of Diabetes Grant 4-200-421. No other potential conflicts of interest relevant to this article were reported.",
year = "2010",
month = aug,
doi = "10.1007/s11892-010-0120-8",
language = "English (US)",
volume = "10",
pages = "276--282",
journal = "Current diabetes reports",
issn = "1534-4827",
publisher = "Current Medicine Group",
number = "4",
}