Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

Marcelo B. Cavalcante, Tatiana D. Saccon, Allancer D.C. Nunes, James L. Kirkland, Tamara Tchkonia, Augusto Schneider, Michal M. Masternak

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The uterine fibrosis contributes to gestational outcomes. Collagen deposition in the uterus is related to uterine aging. Senolytic therapies are an option for reducing health complications related to aging. We investigated effects of aging and the senolytic drug combination of dasatinib plus quercetin (D+Q) on uterine fibrosis. Forty mice, 20 young females (03-months) and 20 old females (18-months), were analyzed. Young (Y) and old (O) animals were divided into groups of 10 mice, with one treatment (T) group (YT and OT) and another control

Original languageEnglish (US)
Pages (from-to)2711-2722
Number of pages12
JournalAging
Volume12
Issue number3
DOIs
StatePublished - Jan 18 2020

Keywords

  • aging
  • miRNA
  • mRNA
  • senolytics
  • uterine fibrosis

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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  • Cite this

    Cavalcante, M. B., Saccon, T. D., Nunes, A. D. C., Kirkland, J. L., Tchkonia, T., Schneider, A., & Masternak, M. M. (2020). Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice. Aging, 12(3), 2711-2722. https://doi.org/10.18632/aging.102772