Dalbavancin is active in vitro against biofilms formed by dalbavancin-susceptible enterococci

Katharina Neudorfer, Suzannah M. Schmidt-Malan, Robin Patel

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We tested the in vitro activity of dalbavancin, vancomycin and daptomycin against 83 enterococcal isolates in planktonic and biofilm states. The MIC90 for vancomycin-susceptible Enterococcus faecalis was 0.125 and 4 μg/mL for dalbavancin and daptomycin, respectively. For vancomycin-resistant Enterococcus faecium, the MIC90 was >16 and 2 μg/mL for dalbavancin and daptomycin, respectively. Dalbavancin minimum biofilm inhibitory concentrations (MBICs) for vancomycin-susceptible and -resistant isolates were ≤0.25 and >16 μg/mL, respectively. The daptomycin MBIC90 for all isolates was 4 μg/mL. For E. faecalis and E. faecium, dalbavancin minimum biofilm bactericidal concentrations (MBBCs) for vancomycin-susceptible and -resistant isolates were ≤4 and >16 μg/mL, respectively, whereas vancomycin MBBCs were >128 μg/mL for all isolates, and daptomycin MBBC90 values for both species were 128 μg/mL. In summary, dalbavancin exhibited in vitro activity against all tested isolates of vancomycin-susceptible, but not against vancomycin-resistant enterococci; activity was observed in both the planktonic and biofilm states.

Original languageEnglish (US)
Pages (from-to)58-63
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume90
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Biofilm
  • Dalbavancin
  • Enterococcus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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