Dalbavancin is active in vitro against biofilms formed by dalbavancin-susceptible enterococci

Katharina Neudorfer, Suzannah M. Schmidt-Malan, Robin Patel

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We tested the in vitro activity of dalbavancin, vancomycin and daptomycin against 83 enterococcal isolates in planktonic and biofilm states. The MIC90 for vancomycin-susceptible Enterococcus faecalis was 0.125 and 4 μg/mL for dalbavancin and daptomycin, respectively. For vancomycin-resistant Enterococcus faecium, the MIC90 was >16 and 2 μg/mL for dalbavancin and daptomycin, respectively. Dalbavancin minimum biofilm inhibitory concentrations (MBICs) for vancomycin-susceptible and -resistant isolates were ≤0.25 and >16 μg/mL, respectively. The daptomycin MBIC90 for all isolates was 4 μg/mL. For E. faecalis and E. faecium, dalbavancin minimum biofilm bactericidal concentrations (MBBCs) for vancomycin-susceptible and -resistant isolates were ≤4 and >16 μg/mL, respectively, whereas vancomycin MBBCs were >128 μg/mL for all isolates, and daptomycin MBBC90 values for both species were 128 μg/mL. In summary, dalbavancin exhibited in vitro activity against all tested isolates of vancomycin-susceptible, but not against vancomycin-resistant enterococci; activity was observed in both the planktonic and biofilm states.

Original languageEnglish (US)
Pages (from-to)58-63
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume90
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • Biofilm
  • Dalbavancin
  • Enterococcus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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