Cytotoxic constituents of Achillea clavennae from Montenegro

Snežana Trifunović; Vlatka Vajs; Zorica Juranić; Željko Žižak; Vele Tešević; Slobodan Macura; Slobodan Milosavljević

doi:10.1016/j.phytochem.2006.02.026

Cytotoxic constituents of Achillea clavennae from Montenegro

Snežana Trifunović, Vlatka Vajs, Zorica Juranić, Željko Žižak, Vele Tešević, Slobodan Macura, Slobodan Milosavljević

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9-11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9α-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound.

Original language	English (US)
Pages (from-to)	887-893
Number of pages	7
Journal	Phytochemistry
Volume	67
Issue number	9
DOIs	https://doi.org/10.1016/j.phytochem.2006.02.026
State	Published - May 2006

Keywords

Achillea clavennae
Asteraceae
Bisabolenes
Cytotoxicity
Flavonoids
Guaianolides

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/j.phytochem.2006.02.026

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title = "Cytotoxic constituents of Achillea clavennae from Montenegro",

abstract = "Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9-11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9α-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound.",

keywords = "Achillea clavennae, Asteraceae, Bisabolenes, Cytotoxicity, Flavonoids, Guaianolides",

author = "Sne{\v z}ana Trifunovi{\'c} and Vlatka Vajs and Zorica Jurani{\'c} and {\v Z}eljko {\v Z}i{\v z}ak and Vele Te{\v s}evi{\'c} and Slobodan Macura and Slobodan Milosavljevi{\'c}",

note = "Funding Information: The authors from Serbia and Montenegro acknowledge their gratitude to the Ministry of Science and Ecology of Serbia for financial support (Projects #142053 and #145006). ",

year = "2006",

month = may,

doi = "10.1016/j.phytochem.2006.02.026",

language = "English (US)",

volume = "67",

pages = "887--893",

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AU - Trifunović, Snežana

AU - Vajs, Vlatka

AU - Juranić, Zorica

AU - Žižak, Željko

AU - Tešević, Vele

AU - Macura, Slobodan

AU - Milosavljević, Slobodan

N1 - Funding Information: The authors from Serbia and Montenegro acknowledge their gratitude to the Ministry of Science and Ecology of Serbia for financial support (Projects #142053 and #145006).

PY - 2006/5

Y1 - 2006/5

N2 - Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9-11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9α-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound.

AB - Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9-11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9α-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound.

KW - Achillea clavennae

KW - Asteraceae

KW - Bisabolenes

KW - Cytotoxicity

KW - Flavonoids

KW - Guaianolides

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SN - 0031-9422

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JO - Phytochemistry

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ER -

Cytotoxic constituents of Achillea clavennae from Montenegro

Abstract

Keywords

ASJC Scopus subject areas

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