Cytotoxic and biochemical implications of combining AZT and AG-331

Medicine & Life Sciences

• AG 331 100%
• Thymidylate Synthase 56%
• raltitrexed 15%
• DNA 13%
• 5'-deoxythymidine 9%
• 3'-azido-3'-deoxythymidine 5'-triphosphate 8%
• dTMP kinase 8%
• thymidine 5'-triphosphate 7%
• Glucuronic Acid 6%
• Single-Stranded DNA Breaks 6%
• indole 6%
• Thymidine Kinase 5%
• Zidovudine 5%
• DNA-Directed DNA Polymerase 5%
• Folic Acid 4%
• Urinary Bladder Neoplasms 4%
• Pharmaceutical Preparations 1%

Chemical Compounds

• Thymidylate Synthase Inhibitor 72%
• ICI D1694 47%
• Glucuronate 17%
• Thymidine 11%
• Indole 9%
• Antitumor 9%
• Drug 5%