Cytoreductive surgery impedes metastasis and enhances the immune response: A preliminary report

Gedas Grinis, Paul Targonski, Michael Shaw, Marvin Rubenstein, Patrick D. Guinan

Research output: Contribution to journalArticle

6 Scopus citations


In an effort to determine the effect of cytoreductive surgery on the metastatic process, MAT‐LyLu flank tumors were excised from Copenhagen X Fischer rats and the effects of this surgery on metastatic lung lesions were observed. Cytoreduction resulted in a decrease in lung lesions (P < 0.05). Adjuvant cyclophosphamide (CTX) further enhanced this beneficial effect. A concurrent increase in the helper/suppressor ratios suggested that this beneficial response might be mediated by the host's immune response.

Original languageEnglish (US)
Pages (from-to)122-126
Number of pages5
JournalJournal of Surgical Oncology
Issue number2
StatePublished - Oct 1991



  • adjuvant chemotherapy
  • immune potentiation
  • therapy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this