In an effort to determine the effect of cytoreductive surgery on the metastatic process, MAT‐LyLu flank tumors were excised from Copenhagen X Fischer rats and the effects of this surgery on metastatic lung lesions were observed. Cytoreduction resulted in a decrease in lung lesions (P < 0.05). Adjuvant cyclophosphamide (CTX) further enhanced this beneficial effect. A concurrent increase in the helper/suppressor ratios suggested that this beneficial response might be mediated by the host's immune response.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Surgical Oncology|
|State||Published - Oct 1991|
- adjuvant chemotherapy
- immune potentiation
ASJC Scopus subject areas