Cytoreductive surgery impedes metastasis and enhances the immune response: A preliminary report

Gedas Grinis; Paul Targonski; Michael Shaw; Marvin Rubenstein; Patrick D. Guinan

doi:10.1002/jso.2930480210

Cytoreductive surgery impedes metastasis and enhances the immune response: A preliminary report

Gedas Grinis, Paul Targonski, Michael Shaw, Marvin Rubenstein, Patrick D. Guinan

Primary Care Internal Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

In an effort to determine the effect of cytoreductive surgery on the metastatic process, MAT‐LyLu flank tumors were excised from Copenhagen X Fischer rats and the effects of this surgery on metastatic lung lesions were observed. Cytoreduction resulted in a decrease in lung lesions (P < 0.05). Adjuvant cyclophosphamide (CTX) further enhanced this beneficial effect. A concurrent increase in the helper/suppressor ratios suggested that this beneficial response might be mediated by the host's immune response.

Original language	English (US)
Pages (from-to)	122-126
Number of pages	5
Journal	Journal of Surgical Oncology
Volume	48
Issue number	2
DOIs	https://doi.org/10.1002/jso.2930480210
State	Published - Oct 1991

Keywords

adjuvant chemotherapy
immune potentiation
therapy

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.2930480210

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abstract = "In an effort to determine the effect of cytoreductive surgery on the metastatic process, MAT‐LyLu flank tumors were excised from Copenhagen X Fischer rats and the effects of this surgery on metastatic lung lesions were observed. Cytoreduction resulted in a decrease in lung lesions (P < 0.05). Adjuvant cyclophosphamide (CTX) further enhanced this beneficial effect. A concurrent increase in the helper/suppressor ratios suggested that this beneficial response might be mediated by the host's immune response.",

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AU - Shaw, Michael

AU - Rubenstein, Marvin

AU - Guinan, Patrick D.

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AB - In an effort to determine the effect of cytoreductive surgery on the metastatic process, MAT‐LyLu flank tumors were excised from Copenhagen X Fischer rats and the effects of this surgery on metastatic lung lesions were observed. Cytoreduction resulted in a decrease in lung lesions (P < 0.05). Adjuvant cyclophosphamide (CTX) further enhanced this beneficial effect. A concurrent increase in the helper/suppressor ratios suggested that this beneficial response might be mediated by the host's immune response.

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KW - therapy

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Cytoreductive surgery impedes metastasis and enhances the immune response: A preliminary report

Abstract

Keywords

ASJC Scopus subject areas

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