Cytopathology of pleural effusions after radiotherapy

K. J. Wojno, J. L. Olson, Mark E. Sherman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The cytomorphology of pleural effusions following ionizing radiotherapy (IRT) has not been studied systematically. To determine if IRT produces alterations in pleural fluids that affect the cytopathologic interpretation of these specimens, two reviewers, without clinical information, independently assessed 55 specimens obtained following IRT and 39 control specimens obtained from nonirradiated cancer patients. None of the 24 cytologic features studied were identified significantly more frequently by both reviewers in the irradiated specimens. Only one feature (bizarre cells) was found to occur significantly more frequently in the irradiated specimens (36% versus 15%, P = .03) by either reviewer (reviewer B). Four other features showed a tendency to occur more frequently in the irradiated fluids by one or the other reviewer. They included degenerative changes (27% versus 13%, P = .09 [reviewer A]), smudgy chromatin (16% versus 5%, P = .09 [reviewer A]), large cytoplasmic vacuoles deforming the nuclei (44% versus 26%, P = .07 [reviewer B]) and cytomegaly (38% versus 23%, P = .12 [reviewer B]). The utility of these five features in identifying irradiated specimens was rigorously retested in a second masked review conducted jointly by the two pathologists. None of these features was found more frequently in the irradiated specimens in the second analysis. The results suggest that IRT does not consistently produce distinctive cytologic changes in pleural effusions and that a history of IRT should not affect the interpretation of these specimens.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalActa Cytologica
Volume38
Issue number1
StatePublished - 1994
Externally publishedYes

Fingerprint

Pleural Effusion
Radiotherapy
Vacuoles
Chromatin
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Cytopathology of pleural effusions after radiotherapy. / Wojno, K. J.; Olson, J. L.; Sherman, Mark E.

In: Acta Cytologica, Vol. 38, No. 1, 1994, p. 1-8.

Research output: Contribution to journalArticle

Wojno, KJ, Olson, JL & Sherman, ME 1994, 'Cytopathology of pleural effusions after radiotherapy', Acta Cytologica, vol. 38, no. 1, pp. 1-8.
Wojno, K. J. ; Olson, J. L. ; Sherman, Mark E. / Cytopathology of pleural effusions after radiotherapy. In: Acta Cytologica. 1994 ; Vol. 38, No. 1. pp. 1-8.
@article{3e670df0a3c8447fb8a6a104df85d5c7,
title = "Cytopathology of pleural effusions after radiotherapy",
abstract = "The cytomorphology of pleural effusions following ionizing radiotherapy (IRT) has not been studied systematically. To determine if IRT produces alterations in pleural fluids that affect the cytopathologic interpretation of these specimens, two reviewers, without clinical information, independently assessed 55 specimens obtained following IRT and 39 control specimens obtained from nonirradiated cancer patients. None of the 24 cytologic features studied were identified significantly more frequently by both reviewers in the irradiated specimens. Only one feature (bizarre cells) was found to occur significantly more frequently in the irradiated specimens (36{\%} versus 15{\%}, P = .03) by either reviewer (reviewer B). Four other features showed a tendency to occur more frequently in the irradiated fluids by one or the other reviewer. They included degenerative changes (27{\%} versus 13{\%}, P = .09 [reviewer A]), smudgy chromatin (16{\%} versus 5{\%}, P = .09 [reviewer A]), large cytoplasmic vacuoles deforming the nuclei (44{\%} versus 26{\%}, P = .07 [reviewer B]) and cytomegaly (38{\%} versus 23{\%}, P = .12 [reviewer B]). The utility of these five features in identifying irradiated specimens was rigorously retested in a second masked review conducted jointly by the two pathologists. None of these features was found more frequently in the irradiated specimens in the second analysis. The results suggest that IRT does not consistently produce distinctive cytologic changes in pleural effusions and that a history of IRT should not affect the interpretation of these specimens.",
author = "Wojno, {K. J.} and Olson, {J. L.} and Sherman, {Mark E.}",
year = "1994",
language = "English (US)",
volume = "38",
pages = "1--8",
journal = "Acta Cytologica",
issn = "0001-5547",
publisher = "Science Printers and Publishers Inc.",
number = "1",

}

TY - JOUR

T1 - Cytopathology of pleural effusions after radiotherapy

AU - Wojno, K. J.

AU - Olson, J. L.

AU - Sherman, Mark E.

PY - 1994

Y1 - 1994

N2 - The cytomorphology of pleural effusions following ionizing radiotherapy (IRT) has not been studied systematically. To determine if IRT produces alterations in pleural fluids that affect the cytopathologic interpretation of these specimens, two reviewers, without clinical information, independently assessed 55 specimens obtained following IRT and 39 control specimens obtained from nonirradiated cancer patients. None of the 24 cytologic features studied were identified significantly more frequently by both reviewers in the irradiated specimens. Only one feature (bizarre cells) was found to occur significantly more frequently in the irradiated specimens (36% versus 15%, P = .03) by either reviewer (reviewer B). Four other features showed a tendency to occur more frequently in the irradiated fluids by one or the other reviewer. They included degenerative changes (27% versus 13%, P = .09 [reviewer A]), smudgy chromatin (16% versus 5%, P = .09 [reviewer A]), large cytoplasmic vacuoles deforming the nuclei (44% versus 26%, P = .07 [reviewer B]) and cytomegaly (38% versus 23%, P = .12 [reviewer B]). The utility of these five features in identifying irradiated specimens was rigorously retested in a second masked review conducted jointly by the two pathologists. None of these features was found more frequently in the irradiated specimens in the second analysis. The results suggest that IRT does not consistently produce distinctive cytologic changes in pleural effusions and that a history of IRT should not affect the interpretation of these specimens.

AB - The cytomorphology of pleural effusions following ionizing radiotherapy (IRT) has not been studied systematically. To determine if IRT produces alterations in pleural fluids that affect the cytopathologic interpretation of these specimens, two reviewers, without clinical information, independently assessed 55 specimens obtained following IRT and 39 control specimens obtained from nonirradiated cancer patients. None of the 24 cytologic features studied were identified significantly more frequently by both reviewers in the irradiated specimens. Only one feature (bizarre cells) was found to occur significantly more frequently in the irradiated specimens (36% versus 15%, P = .03) by either reviewer (reviewer B). Four other features showed a tendency to occur more frequently in the irradiated fluids by one or the other reviewer. They included degenerative changes (27% versus 13%, P = .09 [reviewer A]), smudgy chromatin (16% versus 5%, P = .09 [reviewer A]), large cytoplasmic vacuoles deforming the nuclei (44% versus 26%, P = .07 [reviewer B]) and cytomegaly (38% versus 23%, P = .12 [reviewer B]). The utility of these five features in identifying irradiated specimens was rigorously retested in a second masked review conducted jointly by the two pathologists. None of these features was found more frequently in the irradiated specimens in the second analysis. The results suggest that IRT does not consistently produce distinctive cytologic changes in pleural effusions and that a history of IRT should not affect the interpretation of these specimens.

UR - http://www.scopus.com/inward/record.url?scp=0027979932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027979932&partnerID=8YFLogxK

M3 - Article

C2 - 8291345

AN - SCOPUS:0027979932

VL - 38

SP - 1

EP - 8

JO - Acta Cytologica

JF - Acta Cytologica

SN - 0001-5547

IS - 1

ER -