Cytomegalovirus infections in solid organ transplantation

A review

Poornima Ramanan, Raymund R Razonable

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) continues to have a tremendous impact in solid organ transplantation despite remarkable advances in its diagnosis, prevention and treatment. It can affect allograft function and increase patient morbidity and mortality through a number of direct and indirect effects. Patients may develop asymptomatic viremia, CMV syndrome or tissue-invasive disease. Late-onset CMV disease continues to be a major problem in high-risk patients after completion of antiviral prophylaxis. Emerging data suggests that immunologic monitoring may be useful in predicting the risk of late onset CMV disease. There is now increasing interest in the development of an effective vaccine for prevention. Novel antiviral drugs with unique mechanisms of action and lesser toxicity are being developed. Viral load quantification is now undergoing standardization, and this will permit the generation of clinically relevant viral thresholds for the management of patients. This article provides a brief overview of the contemporary epidemiology, clinical presentation, diagnosis, prevention and treatment of CMV infection in solid organ transplant recipients.

Original languageEnglish (US)
Pages (from-to)260-271
Number of pages12
JournalInfection and Chemotherapy
Volume45
Issue number3
DOIs
StatePublished - May 2013

Fingerprint

Cytomegalovirus Infections
Organ Transplantation
Cytomegalovirus
Antiviral Agents
Immunologic Monitoring
Viremia
Viral Load
Allografts
Epidemiology
Vaccines
Morbidity
Transplants
Mortality
Therapeutics
Late Onset Disorders

Keywords

  • Cytomegalovirus
  • Diagnosis
  • Prevention
  • Transplant
  • Treatment

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Cytomegalovirus infections in solid organ transplantation : A review. / Ramanan, Poornima; Razonable, Raymund R.

In: Infection and Chemotherapy, Vol. 45, No. 3, 05.2013, p. 260-271.

Research output: Contribution to journalArticle

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