Cytomegalovirus hepatitis in liver transplantation: Prospective analysis of 93 consecutive orthotopic liver transplantations

C. V. Paya, P. E. Hermans, R. H. Wiesner, J. Ludwig, T. F. Smith, Jorge Rakela, R. A F Krom

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Abstract

Ninety-three consecutive orthotopic liver transplantations in 78 patients were followed prospectively to study the incidence of cytomegalovirus (CMV) hepatitis. CMV hepatitis occurred in 13 (17%). The diagnosis was established by both histology and culture in 5, only by histology in 6, and only by culture in 2. All 13 patients had CMV viruria and 9 had viremia at diagnosis. CMV hepatitis developed in 64% of CMV-seronegative (pretransplantation) patients who received a liver from a CMV-seropositive donor, compared with 3% or 6% of CMV-seropositive patients who received a liver from a CMV-seronegative or CMV-seropositive donor, respectively (P < .001). CMV hepatitis was not a cause of fulminant or irreversible liver dysfunction in any of the 13 cases. Ganciclovir was administered to 6 of the 13 patients and was associated with clinical and virologic cure in 5. CMV hepatitis was self-limited in patients not treated with ganciclovir (illness less severe). The presence of inclusions within the liver tissue correlated with active disease.

Original languageEnglish (US)
Pages (from-to)752-758
Number of pages7
JournalJournal of Infectious Diseases
Volume160
Issue number5
StatePublished - 1989

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Cytomegalovirus
Liver Transplantation
Hepatitis
Ganciclovir
Liver
Histology
Tissue Donors
Viremia
Liver Diseases
Cohort Studies

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Paya, C. V., Hermans, P. E., Wiesner, R. H., Ludwig, J., Smith, T. F., Rakela, J., & Krom, R. A. F. (1989). Cytomegalovirus hepatitis in liver transplantation: Prospective analysis of 93 consecutive orthotopic liver transplantations. Journal of Infectious Diseases, 160(5), 752-758.

Cytomegalovirus hepatitis in liver transplantation : Prospective analysis of 93 consecutive orthotopic liver transplantations. / Paya, C. V.; Hermans, P. E.; Wiesner, R. H.; Ludwig, J.; Smith, T. F.; Rakela, Jorge; Krom, R. A F.

In: Journal of Infectious Diseases, Vol. 160, No. 5, 1989, p. 752-758.

Research output: Contribution to journalArticle

Paya, CV, Hermans, PE, Wiesner, RH, Ludwig, J, Smith, TF, Rakela, J & Krom, RAF 1989, 'Cytomegalovirus hepatitis in liver transplantation: Prospective analysis of 93 consecutive orthotopic liver transplantations', Journal of Infectious Diseases, vol. 160, no. 5, pp. 752-758.
Paya, C. V. ; Hermans, P. E. ; Wiesner, R. H. ; Ludwig, J. ; Smith, T. F. ; Rakela, Jorge ; Krom, R. A F. / Cytomegalovirus hepatitis in liver transplantation : Prospective analysis of 93 consecutive orthotopic liver transplantations. In: Journal of Infectious Diseases. 1989 ; Vol. 160, No. 5. pp. 752-758.
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