Cytomegalovirus Hepatitis in Liver Transplantation: Prospective Analysis of 93 Consecutive Orthotopic Liver Transplantations

Carlos V. Paya, Paul E. Hermans, Russell H. Wiesner, Jurgen Ludwig, Thomas F. Smith, Jorge Rakela, Ruud A.F. Krom

Research output: Contribution to journalArticlepeer-review

118 Scopus citations

Abstract

Ninety-three consecutive orthotopic liver transplantations in 78 patients were followed prospectively to study the incidence of cytomegalovirus (CMV) hepatitis. CM V hepatitis occurred in 13 (17%). The diagnosis was established by both histology and culture in 5, only by histology in 6, and only by culture in 2. All 13 patients had CMV viruria and 9 had viremia at diagnosis. CMV hepatitis developed in 64% of CMV-seronegative (pretransplantation) patients who received a liver from a CMV-seropositive donor, compared with 3% or 6% of CMV-seropositive patients who received a liver from a CMV- seronegative or CMV-seropositive donor, respectively (P <.001). CMV hepatitis was not a cause of fulminant or irreversible liver dysfunction in any of the 13 cases. Ganciclovir was administered to 6 of the 13 patients and was associated with clinical and virologic cure in 5. CMV hepatitis was self-limited in patients not treated with ganciclovir (illness less severe). The presence of inclusions within the liver tissue correlated with active disease.

Original languageEnglish (US)
Pages (from-to)752-758
Number of pages7
JournalJournal of Infectious Diseases
Volume160
Issue number5
DOIs
StatePublished - Nov 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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