Cytomegalovirus as an exacerbating factor in ulcerative colitis

Edward Vincent Loftus, Jr, Glenn L. Alexander, Herschel A. Carpenter

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) colitis has been reported infrequently in patients with underlying inflammatory bowel disease, and usually in those who are taking long-term corticosteroid drugs and who are potentially immunosuppressed. We report a 39-year-old man with longstanding ulcerative colitis, taking only sulfasalazine, who developed a viral prodrome followed by bloody diarrhea. Severe colitis was noted on endoscopy. He worsened with intravenous steroid and antibiotic drugs. Flexible sigmoidoscopy with biopsy before a contemplated colectomy revealed a moderately active colitis with large cells containing intranuclear inclusions scattered throughout the biopsies, characteristic of CMV colitis. Serologic and immunologic studies suggested recent CMV infection. The patient improved with intravenous ganciclovir and a steroid taper, and colectomy was avoided. CMV colitis is a potentially treatable cause of fulminant colitis.

Original languageEnglish (US)
Pages (from-to)306-309
Number of pages4
JournalJournal of Clinical Gastroenterology
Volume19
Issue number4
StatePublished - 1994

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Colitis
Cytomegalovirus
Ulcerative Colitis
Colectomy
Steroids
Biopsy
Intranuclear Inclusion Bodies
Sigmoidoscopy
Sulfasalazine
Ganciclovir
Cytomegalovirus Infections
Inflammatory Bowel Diseases
Pharmaceutical Preparations
Endoscopy
Diarrhea
Adrenal Cortex Hormones
Anti-Bacterial Agents

Keywords

  • Cytomegalovirus infections
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cytomegalovirus as an exacerbating factor in ulcerative colitis. / Loftus, Jr, Edward Vincent; Alexander, Glenn L.; Carpenter, Herschel A.

In: Journal of Clinical Gastroenterology, Vol. 19, No. 4, 1994, p. 306-309.

Research output: Contribution to journalArticle

Loftus, Jr, Edward Vincent ; Alexander, Glenn L. ; Carpenter, Herschel A. / Cytomegalovirus as an exacerbating factor in ulcerative colitis. In: Journal of Clinical Gastroenterology. 1994 ; Vol. 19, No. 4. pp. 306-309.
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