Cytological screening for Barrett’s esophagus using a prototype flexible mesh catheter

Anne E. Rader, Douglas O. Faigel, John Ditomasso, Nathan Magaret, Michael Burm, M. Brian Fennerty

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The current cost of endoscopically screening patients with gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE) is considerable. A nonendoscopic device that allows for screening of these patients would offer significant cost savings. This pilot study evaluates the utility of cytologically diagnosing BE using a prototype flexible mesh catheter. Patients with known BE undergoing indicated surveillance endoscopy were enrolled in the study. Cytology specimens were obtained using a prototype flexible catheter and were evaluated for the presence of glandular cells, goblet cells, squamous cells, inflammation, and dysplasia. Eleven patients with BE were enrolled in the study. None of the patients experienced complications. Specimens from eight patients (73%) were adequate for evaluation and seven of these patients (87.5%) had goblet cells diagnostic for BE. In conclusion, flexible mesh catheters potentially offer a sensitive, inexpensive, and minimally invasive approach to evaluating patients with GERD and BE.

Original languageEnglish (US)
Article number364234
Pages (from-to)2681-2686
Number of pages6
JournalDigestive Diseases and Sciences
Volume46
Issue number12
DOIs
StatePublished - Jan 1 2001

Keywords

  • Barrett's esophagus
  • Catheter
  • Gastroesophageal reflux disease
  • Screening

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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