Cytokine receptor signaling mechanisms

Larry M Karnitz, Robert T. Abraham

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Recent studies have dramatically advanced our understanding of the post-receptor signaling machinery engaged by members of the cytokine receptor superfamily. Proximal components of this signaling machinery are members of a novel class of protein tyrosine kinases termed JAKs. A working model proposes that ligand-induced dimerization of cytokine receptor subunits triggers the catalytic activation of the associated JAKs, which then couple the receptor to downstream signaling pathways. Ongoing research efforts are also yielding information regarding two potentially interactive pathways of nuclear signaling activated by cytokine receptor occupancy. These pathways are initiated by the activation of the Ras to mitogen-activated protein (MAP) kinase cascade and by the tyrosine phosphorylation of a newly defined set of transcription factors, the signal transducers and activators of transcription (STATs). Collectively, these results begin to provide a molecular basis for the long-observed phenomena of cytokine pleiotropy and redundancy.

Original languageEnglish (US)
Pages (from-to)320-326
Number of pages7
JournalCurrent Opinion in Immunology
Volume7
Issue number3
DOIs
StatePublished - 1995

Fingerprint

Cytokine Receptors
Dimerization
Mitogen-Activated Protein Kinases
Transducers
Protein-Tyrosine Kinases
Tyrosine
Catalytic Domain
Transcription Factors
Phosphorylation
Cytokines
Ligands
Research

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Cytokine receptor signaling mechanisms. / Karnitz, Larry M; Abraham, Robert T.

In: Current Opinion in Immunology, Vol. 7, No. 3, 1995, p. 320-326.

Research output: Contribution to journalArticle

Karnitz, Larry M ; Abraham, Robert T. / Cytokine receptor signaling mechanisms. In: Current Opinion in Immunology. 1995 ; Vol. 7, No. 3. pp. 320-326.
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