TY - JOUR
T1 - Cytokine expression and microglial activation in progressive supranuclear palsy
AU - Fernández-Botrán, Rafael
AU - Ahmed, Zeshan
AU - Crespo, Fabián A.
AU - Gatenbee, Chandler
AU - Gonzalez, John
AU - Dickson, Dennis W.
AU - Litvan, Irene
N1 - Funding Information:
We are indebted to the CurePSP brain bank for making the study samples available. Funded in part by American Heart Association grant 0350352N to R.F.B. Dr. Dickson is supported by NIH grants P50NS072187 and P50AG16475 and Dr. Litvan NIH grant R01 PAS-03-092 .
PY - 2011/11
Y1 - 2011/11
N2 - Although little is known about the etiology of progressive supranuclear palsy (PSP), genetic and epigenetic factors, oxidative injury and inflammation are thought to contribute to its development and/or progression. Evidence for activated glia involvement in PSP has raised the possibility that neuroinflammation may contribute to its pathogenesis. To investigate the correlation between neuroinflammation and PSP, a comparative study was conducted on the patterns of cytokine expression in different regions of the brains of PSP, Alzheimer's disease (AD) patients and normal controls. Our results show different patterns of cytokine expression in each disease, with the expression of IL-1β transcripts being significantly higher in the substantia nigra of PSP than in AD and controls, while AD brains had significantly higher IL-1β expression in the parietal cortex compared to PSP and controls. In addition, expression of TGFβ was significantly higher in the cortical areas (particularly frontal and parietal lobes) of AD compared to PSP and controls. These results show a disease-specific topographical relationship among the expression of certain cytokines (IL-1β and TGFβ), microglial activation and neurodegenerative changes, suggesting that these cytokines may contribute to the pathologic process. If so, the use of cytokine-inhibitors and/or other anti-inflammatory agents may be able to slow disease progression in PSP.
AB - Although little is known about the etiology of progressive supranuclear palsy (PSP), genetic and epigenetic factors, oxidative injury and inflammation are thought to contribute to its development and/or progression. Evidence for activated glia involvement in PSP has raised the possibility that neuroinflammation may contribute to its pathogenesis. To investigate the correlation between neuroinflammation and PSP, a comparative study was conducted on the patterns of cytokine expression in different regions of the brains of PSP, Alzheimer's disease (AD) patients and normal controls. Our results show different patterns of cytokine expression in each disease, with the expression of IL-1β transcripts being significantly higher in the substantia nigra of PSP than in AD and controls, while AD brains had significantly higher IL-1β expression in the parietal cortex compared to PSP and controls. In addition, expression of TGFβ was significantly higher in the cortical areas (particularly frontal and parietal lobes) of AD compared to PSP and controls. These results show a disease-specific topographical relationship among the expression of certain cytokines (IL-1β and TGFβ), microglial activation and neurodegenerative changes, suggesting that these cytokines may contribute to the pathologic process. If so, the use of cytokine-inhibitors and/or other anti-inflammatory agents may be able to slow disease progression in PSP.
KW - Alzheimer's disease
KW - Brain
KW - Cytokines
KW - Inflammation
KW - Microglia
KW - Progressive supranuclear palsy
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U2 - 10.1016/j.parkreldis.2011.06.007
DO - 10.1016/j.parkreldis.2011.06.007
M3 - Article
C2 - 21741294
AN - SCOPUS:80054855155
VL - 17
SP - 683
EP - 688
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
SN - 1353-8020
IS - 9
ER -