Cytogenetic studies of epithelial ovarian carcinoma

Robert B. Jenkins, Duane Bartelt, Paul Stalboerger, Diane Persons, Richard J. Dahl, Karl Podratz, Gary Keeney, Lynn Hartmann

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

We performed cytogenetic studies of 36 human epithelial ovarian carcinomas using in situ culture and robotic harvest. We obtained analyzable metaphases of all 36 tumors (100%). One or more chromosomally abnormal clones were observed in 80% of tumors. Common clonal chromosome gains (each occurring in six or more cases) included +1, +2, +3, +6, +7, +9, and +12. Common clonal chromosome losses (occurring in 12 or more cases) included -X, -4, -8, -11, -13, -15, -17, and -22. Common clonal structural abnormalities (occurring in four or more cases) involved regions 1p36, 1q32, 1q42, 3p13→p26, 3q26→q29, 7p22, 9q34, 11p13-p15, 17q1→q23, 19p13.3, and 19q13.3. Trisomy 12 was noted as the sole anomaly in three of five borderline and grade 1 tumors. Two grade 2 tumors contained i(1q), -14, -15 and -22. The results suggest that the pathogenesis of borderline and low-grade tumors may differ from that of higher grade tumors. Two high-grade tumors had an apparent translocation between 17q21 and 19p13.3, two chromosome regions believed to be critical to ovarian carcinogenesis.

Original languageEnglish (US)
Pages (from-to)76-86
Number of pages11
JournalCancer Genetics and Cytogenetics
Volume71
Issue number1
DOIs
StatePublished - Nov 1993

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Jenkins, R. B., Bartelt, D., Stalboerger, P., Persons, D., Dahl, R. J., Podratz, K., Keeney, G., & Hartmann, L. (1993). Cytogenetic studies of epithelial ovarian carcinoma. Cancer Genetics and Cytogenetics, 71(1), 76-86. https://doi.org/10.1016/0165-4608(93)90205-Z