Cytogenetic studies at diagnosis in polycythemia vera: Clinical and JAK2V617F allele burden correlates

Naseema Gangat, Jacob Strand, Terra L. Lasho, Christy M. Finke, Ryan A. Knudson, Animesh D Pardanani, Chin Yang Li, Rhett P. Ketterling, Ayalew Tefferi

Research output: Contribution to journalArticle

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Abstract

The prognostic significance of cytogenetic findings at diagnosis in polycythemia vera (PV) was investigated in a retrospective series of 137 patients. Cytogenetics were normal in 117 patients (85%) and displayed a -Y abnormality in five patients (7% of male patients), and other chromosomal abnormalities in 15 patients (11%). The most frequent cytogenetic anomalies were trisomy 8 (n = 4), trisomy 9 (n = 2), deletion 20q (n = 2) and chromosomal 1 abnormalities (n = 2). Parameters that were significantly associated with abnormal cytogenetics included age ≥60 yr (P = 0.02), but not JAK2V617F allele burden, thrombosis, hemorrhage, leukemic/fibrotic transformation, or survival. We conclude that cytogenetic anomalies occur infrequently at PV diagnosis and do not confer an adverse outcome.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalEuropean Journal of Haematology
Volume80
Issue number3
DOIs
StatePublished - Mar 2008

Fingerprint

Polycythemia Vera
Cytogenetics
Alleles
Chromosome Aberrations
Thrombosis
Hemorrhage
Survival

Keywords

  • Cytogenetics
  • Karyotype
  • Myeloid disorders
  • Polycythemia vera

ASJC Scopus subject areas

  • Hematology

Cite this

Cytogenetic studies at diagnosis in polycythemia vera : Clinical and JAK2V617F allele burden correlates. / Gangat, Naseema; Strand, Jacob; Lasho, Terra L.; Finke, Christy M.; Knudson, Ryan A.; Pardanani, Animesh D; Li, Chin Yang; Ketterling, Rhett P.; Tefferi, Ayalew.

In: European Journal of Haematology, Vol. 80, No. 3, 03.2008, p. 197-200.

Research output: Contribution to journalArticle

Gangat, Naseema ; Strand, Jacob ; Lasho, Terra L. ; Finke, Christy M. ; Knudson, Ryan A. ; Pardanani, Animesh D ; Li, Chin Yang ; Ketterling, Rhett P. ; Tefferi, Ayalew. / Cytogenetic studies at diagnosis in polycythemia vera : Clinical and JAK2V617F allele burden correlates. In: European Journal of Haematology. 2008 ; Vol. 80, No. 3. pp. 197-200.
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