Cytogenetic findings and survival in b-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients

Gunnar Juliusson, David Oscier, G. Juliusson, G. Gahrton, D. Oscier, M. Fitchett, F. Ross, V. Brito-Babapulle, D. Catovsky, S. Knuutila, E. Elonen, M. Lechleitner, J. Tanzer, M. Schoenwald, G. L. Castoldi, A. Cuneo, P. Nowell, L. Peterson, N. Kay

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

Chromosome analysis on CLL-cells from 649 patients revealed clonal changes in 311 cases (48% The most common abnormalities were trisomy 12 (n = 112), and structural changes on the long arm of chromosome 13 (n = 62), most of them interstitial deletions or translocations involving 13q14, the site of the retinoblastoma gene. Complex karyotypes were associated with poor prognosis, although karyotypic changes rarely develop during the course of the disease. Among patients with single chromosomal abnormalities those with trisomy 12 had a poor survival, whereas those with structural changes on chromosome 13 had as good a prognosis as patients with a normal karyotype.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalLeukemia and Lymphoma
Volume5
Issue numberS1
DOIs
StatePublished - Jan 1 1991

Keywords

  • CLL
  • Cytogenetic findings
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Juliusson, G., Oscier, D., Juliusson, G., Gahrton, G., Oscier, D., Fitchett, M., Ross, F., Brito-Babapulle, V., Catovsky, D., Knuutila, S., Elonen, E., Lechleitner, M., Tanzer, J., Schoenwald, M., Castoldi, G. L., Cuneo, A., Nowell, P., Peterson, L., & Kay, N. (1991). Cytogenetic findings and survival in b-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients. Leukemia and Lymphoma, 5(S1), 21-25. https://doi.org/10.3109/10428199109103374