Cytogenetic and molecular genetic methods for diagnosis and treatment response in chronic granulocytic leukemia

Gordon W. Dewald, Amy L. Juneau, Christopher R. Schad, Ayalew Tefferi

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Today, laboratory geneticists help clinical hematologists diagnose chronic granulocytic leukemia (CGL) and monitor the response of patients undergoing treatment. The most common genetic tests for CGL include quantitative cytogenetic studies, fluorescence in situ hybridization with probes for BCR and ABL, Southern blot analysis, and reverse transcriptase polymerase chain reaction. No single genetic testing procedure fulfills all the needs of clinicians who care for patients who have CGL. Thus, it has become important to use combinations of testing methods that are both accurate and cost-effective for any given clinical situation in the diagnosis and treatment of patients with CGL.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume94
Issue number1
DOIs
StatePublished - Mar 1997

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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