Cytogenetic and molecular cytogenetic findings in dedifferentiated liposarcoma with neural-like whorling pattern and metaplastic bone formation

Ricardo S. Macarenco, Michele Erickson-Johnson, Xiaoke Wang, Robert Brian Jenkins, Antonio G. Nascimento, Andre M. Oliveira

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Dedifferentiated liposarcoma is a subtype of liposarcoma characterized by juxtaposition of well-differentiated liposarcoma with a nonadipocytic sarcoma. A peculiar form of dedifferentiated liposarcoma has been described, characterized by a nonlipogenic component with a neural-like whorling pattern of growth and metaplastic bone formation. We report the cytogenetic and molecular genetic findings of this peculiar form of dedifferentiation in a retroperitoneal tumor found in a 58-year-old female. The neoplasm had typical histologic findings and a complex karyotype characterized by several numeric and structural chromosomal abnormalities, including the presence of ring and giant rod chromosomes. Molecular cytogenetic studies found high levels of amplification of the MDM2 oncogene, consistent with the amplification of the 12q14 chromosome band, a cytogenetic abnormality commonly found in these tumors. These findings indicate that, despite its unique and peculiar morphologic features, this unusual type of dedifferentiated liposarcoma shares many of the cytogenetic features and molecular genetic abnormalities found in other forms of dedifferentiation. The specific cytogenetics and molecular determinants of these peculiar morphologic findings, however, remain unknown.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume172
Issue number2
DOIs
StatePublished - Jan 15 2007

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Liposarcoma
Osteogenesis
Cytogenetics
Chromosome Aberrations
Molecular Biology
Chromosomes
Neoplasms
Karyotype
Oncogenes
Sarcoma
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Cytogenetic and molecular cytogenetic findings in dedifferentiated liposarcoma with neural-like whorling pattern and metaplastic bone formation. / Macarenco, Ricardo S.; Erickson-Johnson, Michele; Wang, Xiaoke; Jenkins, Robert Brian; Nascimento, Antonio G.; Oliveira, Andre M.

In: Cancer Genetics and Cytogenetics, Vol. 172, No. 2, 15.01.2007, p. 147-150.

Research output: Contribution to journalArticle

Macarenco, Ricardo S. ; Erickson-Johnson, Michele ; Wang, Xiaoke ; Jenkins, Robert Brian ; Nascimento, Antonio G. ; Oliveira, Andre M. / Cytogenetic and molecular cytogenetic findings in dedifferentiated liposarcoma with neural-like whorling pattern and metaplastic bone formation. In: Cancer Genetics and Cytogenetics. 2007 ; Vol. 172, No. 2. pp. 147-150.
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