Cytogenetic and loss of heterozygosity studies in ependymomas, pilocytic astrocytomas, and oligodendrogliomas

D. T. Ransom, S. R. Ritland, D. W. Kimmel, C. A. Moertel, R. J. Dahl, B. W. Scheithauer, P. J. Kelly, Robert Brian Jenkins

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Abstract

Cytogenetic and/or loss of heterozygosity studies were performed on 13 ependymomas, 11 pilocytic astrocytomas, and 18 oligodendrogliomas. Loss of chromosome 22 was the most frequent genetic abnormality among the ependymomas. We found no consistent genetic abnormality in pilocytic astrocytomas. The most common genetic abnormality in oligodendrogliomas was loss of a portion of chromosome 19. Each informative oligodendroglioma had loss of alleles mapped to the long arm (q) of chromosome 19. One oligodendroglioma had an apparent homozygous deletion of the D19S8 locus. Our results, when combined with those in the literature, indicate that chromosomes 9, 11, and 22 may harbor genes important for the pathogenesis of ependymomas and that 19q probably harbors a gene important for the pathogenesis of oligodendrogliomas.

Original languageEnglish (US)
Pages (from-to)348-356
Number of pages9
JournalGenes Chromosomes and Cancer
Volume5
Issue number4
DOIs
StatePublished - 1992

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Oligodendroglioma
Ependymoma
Loss of Heterozygosity
Astrocytoma
Cytogenetics
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 11
Genes
Alleles

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Cytogenetic and loss of heterozygosity studies in ependymomas, pilocytic astrocytomas, and oligodendrogliomas. / Ransom, D. T.; Ritland, S. R.; Kimmel, D. W.; Moertel, C. A.; Dahl, R. J.; Scheithauer, B. W.; Kelly, P. J.; Jenkins, Robert Brian.

In: Genes Chromosomes and Cancer, Vol. 5, No. 4, 1992, p. 348-356.

Research output: Contribution to journalArticle

Ransom, DT, Ritland, SR, Kimmel, DW, Moertel, CA, Dahl, RJ, Scheithauer, BW, Kelly, PJ & Jenkins, RB 1992, 'Cytogenetic and loss of heterozygosity studies in ependymomas, pilocytic astrocytomas, and oligodendrogliomas', Genes Chromosomes and Cancer, vol. 5, no. 4, pp. 348-356. https://doi.org/10.1002/gcc.2870050411
Ransom, D. T. ; Ritland, S. R. ; Kimmel, D. W. ; Moertel, C. A. ; Dahl, R. J. ; Scheithauer, B. W. ; Kelly, P. J. ; Jenkins, Robert Brian. / Cytogenetic and loss of heterozygosity studies in ependymomas, pilocytic astrocytomas, and oligodendrogliomas. In: Genes Chromosomes and Cancer. 1992 ; Vol. 5, No. 4. pp. 348-356.
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AU - Ritland, S. R.

AU - Kimmel, D. W.

AU - Moertel, C. A.

AU - Dahl, R. J.

AU - Scheithauer, B. W.

AU - Kelly, P. J.

AU - Jenkins, Robert Brian

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