Cytogenetic analysis of six renal oncocytomas and a chromophobe cell renal carcinoma. Evidence that -Y,-1 may be a characteristic anomaly in renal oncocytomas

Thomas B. Crotty, Kim M. Lawrence, Cheryl A. Moertel, Duane H. Bartelt, Kenneth P. Batts, Gordon W. Dewald, George M. Farrow, Robert Brian Jenkins

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Abstract

Renal oncocytomas are benign tumors whose morphologic features may sometimes be confused with those of certain low-grade malignant neoplasms of the kidney, e.g., chromophobe cell and granular cell variants of renal carcinoma. The presence of a specific genetic abnormality might help differentiate these tumors. Because very few cytogenetic studies of renal oncocytomas have been published, we investigated a consecutive series of six such tumors. We also performed chromosome analysis on a chromophobe cell carcinoma because cytogenetic analyses of this tumor have not been previously reported. Tumor cell metaphases were analyzed after mechanical and enzyme disaggregation, in situ culture, and robotic harvesting. Clonal abnormalities were present in five of the six oncocytomas, and loss of chromosome 1 with loss of the Y chromosome occurred in two. Review of the literature disclosed four other renal oncocytomas with the 44,X,-Y,-1 karyotype. In the chromophobe cell carcinoma, we noted an abnormal clone with a del(11)(p12p15.1); similar anomalies were not observed in the renal oncocytomas. We conclude that renal oncocytomas have clonal chromosome abnormalities and that a subgroup of these tumors may be specifically associated with loss of chromosomes 1 and Y. Because this is a small series, further investigation may help establish whether cytogenetic studies can provide diagnostic and pathogenic information about renal oncocytomas.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume61
Issue number1
DOIs
StatePublished - Jul 1 1992

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Cytogenetic Analysis
Renal Cell Carcinoma
Neoplasms
Chromosomes, Human, Pair 1
Cytogenetics
Oxyphilic Adenoma
Carcinoma
Kidney Neoplasms
Y Chromosome
Robotics
Metaphase
Karyotype
Chromosome Aberrations
Renal oncocytoma
Clone Cells
Chromosomes
Enzymes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Cytogenetic analysis of six renal oncocytomas and a chromophobe cell renal carcinoma. Evidence that -Y,-1 may be a characteristic anomaly in renal oncocytomas. / Crotty, Thomas B.; Lawrence, Kim M.; Moertel, Cheryl A.; Bartelt, Duane H.; Batts, Kenneth P.; Dewald, Gordon W.; Farrow, George M.; Jenkins, Robert Brian.

In: Cancer Genetics and Cytogenetics, Vol. 61, No. 1, 01.07.1992, p. 61-66.

Research output: Contribution to journalArticle

Crotty, Thomas B. ; Lawrence, Kim M. ; Moertel, Cheryl A. ; Bartelt, Duane H. ; Batts, Kenneth P. ; Dewald, Gordon W. ; Farrow, George M. ; Jenkins, Robert Brian. / Cytogenetic analysis of six renal oncocytomas and a chromophobe cell renal carcinoma. Evidence that -Y,-1 may be a characteristic anomaly in renal oncocytomas. In: Cancer Genetics and Cytogenetics. 1992 ; Vol. 61, No. 1. pp. 61-66.
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