TY - JOUR
T1 - Cytogenetic analysis of aggressive meningiomas
T2 - Possible diagnostic and prognostic implications
AU - Perry, Arie
AU - Jenkins, Robert B.
AU - Dahl, Richard J.
AU - Moertel, Cheryl A.
AU - Scheithauer, Bernd W.
PY - 1996/6/15
Y1 - 1996/6/15
N2 - BACKGROUND. Published karyotypes from aggressive (atypical and malignant) meningiomas are few, but suggest clonal evolution from benign tumors with monosomy 22 to aggressive forms with additional abnormalities. The goal of this study was to identify the most frequent karyotypic and biological behavior. METHODS. Eight intracranial meningiomas exhibiting histologically atypical features at the time of intraoperative diagnosis were chosen for cytogenetic analysis. The study set was comprised entirely of histologically atypical meningiomas. Four were considered malignant; three on the basis of brain invasion and one due to extracranial metastases. None was histologically anaplastic. RESULTS. Chromosomal abnormalities were demonstrated in 6 cases (75%), 5 of which were complex (63%). Loss of chromosome 22 was identified in two cases, both of which were associated with additional aberrations. Abnormalities most frequently involved chromosomes 1 (63%), 3 (50%), and 6 (63%). Four cases (50%) had dicentric or ring chromosomes. An additional 47 previously reported karyotypes from atypical and malignant meningiomas were reviewed. Comparison with published karyotypes of 200 histologically benign meningiomas served to under score the increased frequency of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and tolemeric associations in the aggressive tumors. Apparently normal karyotypes as well as monosomy 22 alone were more frequently associated with benign, nontypical histopathology. CONCLUSIONS. These findings suggest a possible role for cytogenetic analysis in determining the prognosis and perhaps in refining the diagnosis of atypical or aggressive meningiomas. Further studies are necessary to determine the significance of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and telomeric associations, particularly whether they portend a more aggressive clinical course in meningiomas lacking features of histologic atypia.
AB - BACKGROUND. Published karyotypes from aggressive (atypical and malignant) meningiomas are few, but suggest clonal evolution from benign tumors with monosomy 22 to aggressive forms with additional abnormalities. The goal of this study was to identify the most frequent karyotypic and biological behavior. METHODS. Eight intracranial meningiomas exhibiting histologically atypical features at the time of intraoperative diagnosis were chosen for cytogenetic analysis. The study set was comprised entirely of histologically atypical meningiomas. Four were considered malignant; three on the basis of brain invasion and one due to extracranial metastases. None was histologically anaplastic. RESULTS. Chromosomal abnormalities were demonstrated in 6 cases (75%), 5 of which were complex (63%). Loss of chromosome 22 was identified in two cases, both of which were associated with additional aberrations. Abnormalities most frequently involved chromosomes 1 (63%), 3 (50%), and 6 (63%). Four cases (50%) had dicentric or ring chromosomes. An additional 47 previously reported karyotypes from atypical and malignant meningiomas were reviewed. Comparison with published karyotypes of 200 histologically benign meningiomas served to under score the increased frequency of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and tolemeric associations in the aggressive tumors. Apparently normal karyotypes as well as monosomy 22 alone were more frequently associated with benign, nontypical histopathology. CONCLUSIONS. These findings suggest a possible role for cytogenetic analysis in determining the prognosis and perhaps in refining the diagnosis of atypical or aggressive meningiomas. Further studies are necessary to determine the significance of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and telomeric associations, particularly whether they portend a more aggressive clinical course in meningiomas lacking features of histologic atypia.
KW - atypical
KW - chromosome 1
KW - chromosome 22
KW - chromosome 3
KW - chromosome 6
KW - karyotype
KW - malignant
KW - meningioma
UR - http://www.scopus.com/inward/record.url?scp=0029951331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029951331&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0142(19960615)77:12<2567::AID-CNCR21>3.0.CO;2-P
DO - 10.1002/(SICI)1097-0142(19960615)77:12<2567::AID-CNCR21>3.0.CO;2-P
M3 - Article
C2 - 8640707
AN - SCOPUS:0029951331
SN - 0008-543X
VL - 77
SP - 2567
EP - 2573
JO - Cancer
JF - Cancer
IS - 12
ER -