Cytogenetic analysis of aggressive meningiomas: Possible diagnostic and prognostic implications

Arie Perry, Robert Brian Jenkins, Richard J. Dahl, Cheryl A. Moertel, Bernd W. Scheithauer

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

BACKGROUND. Published karyotypes from aggressive (atypical and malignant) meningiomas are few, but suggest clonal evolution from benign tumors with monosomy 22 to aggressive forms with additional abnormalities. The goal of this study was to identify the most frequent karyotypic and biological behavior. METHODS. Eight intracranial meningiomas exhibiting histologically atypical features at the time of intraoperative diagnosis were chosen for cytogenetic analysis. The study set was comprised entirely of histologically atypical meningiomas. Four were considered malignant; three on the basis of brain invasion and one due to extracranial metastases. None was histologically anaplastic. RESULTS. Chromosomal abnormalities were demonstrated in 6 cases (75%), 5 of which were complex (63%). Loss of chromosome 22 was identified in two cases, both of which were associated with additional aberrations. Abnormalities most frequently involved chromosomes 1 (63%), 3 (50%), and 6 (63%). Four cases (50%) had dicentric or ring chromosomes. An additional 47 previously reported karyotypes from atypical and malignant meningiomas were reviewed. Comparison with published karyotypes of 200 histologically benign meningiomas served to under score the increased frequency of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and tolemeric associations in the aggressive tumors. Apparently normal karyotypes as well as monosomy 22 alone were more frequently associated with benign, nontypical histopathology. CONCLUSIONS. These findings suggest a possible role for cytogenetic analysis in determining the prognosis and perhaps in refining the diagnosis of atypical or aggressive meningiomas. Further studies are necessary to determine the significance of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and telomeric associations, particularly whether they portend a more aggressive clinical course in meningiomas lacking features of histologic atypia.

Original languageEnglish (US)
Pages (from-to)2567-2573
Number of pages7
JournalCancer
Volume77
Issue number12
DOIs
StatePublished - Jun 15 1996

Fingerprint

Cytogenetic Analysis
Meningioma
Karyotype
Chromosomes, Human, Pair 1
Monosomy
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 3
Clonal Evolution
Ring Chromosomes
Chromosomes, Human, Pair 22
Chromosome Aberrations
Neoplasms
Neoplasm Metastasis
Brain

Keywords

  • atypical
  • chromosome 1
  • chromosome 22
  • chromosome 3
  • chromosome 6
  • karyotype
  • malignant
  • meningioma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cytogenetic analysis of aggressive meningiomas : Possible diagnostic and prognostic implications. / Perry, Arie; Jenkins, Robert Brian; Dahl, Richard J.; Moertel, Cheryl A.; Scheithauer, Bernd W.

In: Cancer, Vol. 77, No. 12, 15.06.1996, p. 2567-2573.

Research output: Contribution to journalArticle

Perry, Arie ; Jenkins, Robert Brian ; Dahl, Richard J. ; Moertel, Cheryl A. ; Scheithauer, Bernd W. / Cytogenetic analysis of aggressive meningiomas : Possible diagnostic and prognostic implications. In: Cancer. 1996 ; Vol. 77, No. 12. pp. 2567-2573.
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abstract = "BACKGROUND. Published karyotypes from aggressive (atypical and malignant) meningiomas are few, but suggest clonal evolution from benign tumors with monosomy 22 to aggressive forms with additional abnormalities. The goal of this study was to identify the most frequent karyotypic and biological behavior. METHODS. Eight intracranial meningiomas exhibiting histologically atypical features at the time of intraoperative diagnosis were chosen for cytogenetic analysis. The study set was comprised entirely of histologically atypical meningiomas. Four were considered malignant; three on the basis of brain invasion and one due to extracranial metastases. None was histologically anaplastic. RESULTS. Chromosomal abnormalities were demonstrated in 6 cases (75{\%}), 5 of which were complex (63{\%}). Loss of chromosome 22 was identified in two cases, both of which were associated with additional aberrations. Abnormalities most frequently involved chromosomes 1 (63{\%}), 3 (50{\%}), and 6 (63{\%}). Four cases (50{\%}) had dicentric or ring chromosomes. An additional 47 previously reported karyotypes from atypical and malignant meningiomas were reviewed. Comparison with published karyotypes of 200 histologically benign meningiomas served to under score the increased frequency of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and tolemeric associations in the aggressive tumors. Apparently normal karyotypes as well as monosomy 22 alone were more frequently associated with benign, nontypical histopathology. CONCLUSIONS. These findings suggest a possible role for cytogenetic analysis in determining the prognosis and perhaps in refining the diagnosis of atypical or aggressive meningiomas. Further studies are necessary to determine the significance of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and telomeric associations, particularly whether they portend a more aggressive clinical course in meningiomas lacking features of histologic atypia.",
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N2 - BACKGROUND. Published karyotypes from aggressive (atypical and malignant) meningiomas are few, but suggest clonal evolution from benign tumors with monosomy 22 to aggressive forms with additional abnormalities. The goal of this study was to identify the most frequent karyotypic and biological behavior. METHODS. Eight intracranial meningiomas exhibiting histologically atypical features at the time of intraoperative diagnosis were chosen for cytogenetic analysis. The study set was comprised entirely of histologically atypical meningiomas. Four were considered malignant; three on the basis of brain invasion and one due to extracranial metastases. None was histologically anaplastic. RESULTS. Chromosomal abnormalities were demonstrated in 6 cases (75%), 5 of which were complex (63%). Loss of chromosome 22 was identified in two cases, both of which were associated with additional aberrations. Abnormalities most frequently involved chromosomes 1 (63%), 3 (50%), and 6 (63%). Four cases (50%) had dicentric or ring chromosomes. An additional 47 previously reported karyotypes from atypical and malignant meningiomas were reviewed. Comparison with published karyotypes of 200 histologically benign meningiomas served to under score the increased frequency of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and tolemeric associations in the aggressive tumors. Apparently normal karyotypes as well as monosomy 22 alone were more frequently associated with benign, nontypical histopathology. CONCLUSIONS. These findings suggest a possible role for cytogenetic analysis in determining the prognosis and perhaps in refining the diagnosis of atypical or aggressive meningiomas. Further studies are necessary to determine the significance of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and telomeric associations, particularly whether they portend a more aggressive clinical course in meningiomas lacking features of histologic atypia.

AB - BACKGROUND. Published karyotypes from aggressive (atypical and malignant) meningiomas are few, but suggest clonal evolution from benign tumors with monosomy 22 to aggressive forms with additional abnormalities. The goal of this study was to identify the most frequent karyotypic and biological behavior. METHODS. Eight intracranial meningiomas exhibiting histologically atypical features at the time of intraoperative diagnosis were chosen for cytogenetic analysis. The study set was comprised entirely of histologically atypical meningiomas. Four were considered malignant; three on the basis of brain invasion and one due to extracranial metastases. None was histologically anaplastic. RESULTS. Chromosomal abnormalities were demonstrated in 6 cases (75%), 5 of which were complex (63%). Loss of chromosome 22 was identified in two cases, both of which were associated with additional aberrations. Abnormalities most frequently involved chromosomes 1 (63%), 3 (50%), and 6 (63%). Four cases (50%) had dicentric or ring chromosomes. An additional 47 previously reported karyotypes from atypical and malignant meningiomas were reviewed. Comparison with published karyotypes of 200 histologically benign meningiomas served to under score the increased frequency of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and tolemeric associations in the aggressive tumors. Apparently normal karyotypes as well as monosomy 22 alone were more frequently associated with benign, nontypical histopathology. CONCLUSIONS. These findings suggest a possible role for cytogenetic analysis in determining the prognosis and perhaps in refining the diagnosis of atypical or aggressive meningiomas. Further studies are necessary to determine the significance of complex karyotypes, chromosome 1, 3, and 6 abnormalities, and telomeric associations, particularly whether they portend a more aggressive clinical course in meningiomas lacking features of histologic atypia.

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KW - chromosome 1

KW - chromosome 22

KW - chromosome 3

KW - chromosome 6

KW - karyotype

KW - malignant

KW - meningioma

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