Cyclosporine in the treatment of psoriatic arthritis

A. K. Gupta, Eric Lawrence Matteson, C. N. Ellis, V. C. Ho, D. C. Tellner, J. J. Voorhees, W. J. McCune

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The short-term efficacy of cyclosporine in the treatment of six patients with moderately severe to severe psoriatic arthritis was evaluated in an open study. Patients received oral cyclosporine (6 mg/kg/d) for eight weeks. In all patients, significant improvement of psoriasis was noted within two to four weeks. At the end of therapy, rheumatologic assessment revealed the following trends in disease activity: a decrease in the number of tender joints, joint tenderness index, duration of morning stiffness, and an increase in grip strength. There was a decrease in the number of swollen joints, joint swelling index, and the time taken to walk 50 ft. Overall disease activity significantly improved as assessed independently by the patient and physician. For psoriasis and psoriatic arthritis, disease activity worsened toward baseline within four weeks of discontinuation of therapy. Short-term, low-dose cyclosporine therapy may be effective in treating psoriasis and psoriatic arthritis.

Original languageEnglish (US)
Pages (from-to)507-510
Number of pages4
JournalArchives of Dermatology
Volume125
Issue number4
StatePublished - 1989
Externally publishedYes

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Psoriatic Arthritis
Cyclosporine
Joints
Psoriasis
Hand Strength
Therapeutics
Physicians

ASJC Scopus subject areas

  • Dermatology

Cite this

Gupta, A. K., Matteson, E. L., Ellis, C. N., Ho, V. C., Tellner, D. C., Voorhees, J. J., & McCune, W. J. (1989). Cyclosporine in the treatment of psoriatic arthritis. Archives of Dermatology, 125(4), 507-510.

Cyclosporine in the treatment of psoriatic arthritis. / Gupta, A. K.; Matteson, Eric Lawrence; Ellis, C. N.; Ho, V. C.; Tellner, D. C.; Voorhees, J. J.; McCune, W. J.

In: Archives of Dermatology, Vol. 125, No. 4, 1989, p. 507-510.

Research output: Contribution to journalArticle

Gupta, AK, Matteson, EL, Ellis, CN, Ho, VC, Tellner, DC, Voorhees, JJ & McCune, WJ 1989, 'Cyclosporine in the treatment of psoriatic arthritis', Archives of Dermatology, vol. 125, no. 4, pp. 507-510.
Gupta AK, Matteson EL, Ellis CN, Ho VC, Tellner DC, Voorhees JJ et al. Cyclosporine in the treatment of psoriatic arthritis. Archives of Dermatology. 1989;125(4):507-510.
Gupta, A. K. ; Matteson, Eric Lawrence ; Ellis, C. N. ; Ho, V. C. ; Tellner, D. C. ; Voorhees, J. J. ; McCune, W. J. / Cyclosporine in the treatment of psoriatic arthritis. In: Archives of Dermatology. 1989 ; Vol. 125, No. 4. pp. 507-510.
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