Cyclin D1 splice variant and risk for non-Hodgkin lymphoma

Sophia S. Wang; Wendy Cozen; Richard K. Severson; Patricia Hartge; James R. Cerhan; Scott Davis; Robert Welch; Nathaniel Rothman; Stephen J. Chanock

doi:10.1007/s00439-006-0212-3

Cyclin D1 splice variant and risk for non-Hodgkin lymphoma

Sophia S. Wang, Wendy Cozen, Richard K. Severson, Patricia Hartge, James R. Cerhan, Scott Davis, Robert Welch, Nathaniel Rothman, Stephen J. Chanock

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (OR_AA = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.

Original language	English (US)
Pages (from-to)	297-300
Number of pages	4
Journal	Human genetics
Volume	120
Issue number	2
DOIs	https://doi.org/10.1007/s00439-006-0212-3
State	Published - Sep 2006

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Cyclin D1 splice variant and risk for non-Hodgkin lymphoma",

abstract = "To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (ORAA = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.",

author = "Wang, {Sophia S.} and Wendy Cozen and Severson, {Richard K.} and Patricia Hartge and Cerhan, {James R.} and Scott Davis and Robert Welch and Nathaniel Rothman and Chanock, {Stephen J.}",

note = "Funding Information: Acknowledgements This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, with Public Health Service (PHS) contracts N01-PC-65064, N01-PC-67008, N01-PC-67009, N01-PC-67010, and N02-PC-71105.",

year = "2006",

month = sep,

doi = "10.1007/s00439-006-0212-3",

language = "English (US)",

volume = "120",

pages = "297--300",

journal = "Human genetics",

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T1 - Cyclin D1 splice variant and risk for non-Hodgkin lymphoma

AU - Wang, Sophia S.

AU - Cozen, Wendy

AU - Severson, Richard K.

AU - Hartge, Patricia

AU - Cerhan, James R.

AU - Davis, Scott

AU - Welch, Robert

AU - Rothman, Nathaniel

AU - Chanock, Stephen J.

N1 - Funding Information: Acknowledgements This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, with Public Health Service (PHS) contracts N01-PC-65064, N01-PC-67008, N01-PC-67009, N01-PC-67010, and N02-PC-71105.

PY - 2006/9

Y1 - 2006/9

N2 - To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (ORAA = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.

AB - To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (ORAA = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.

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SP - 297

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JO - Human genetics

JF - Human genetics

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ER -

Cyclin D1 splice variant and risk for non-Hodgkin lymphoma

Abstract

ASJC Scopus subject areas

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