Cyclin D1 splice variant and risk for non-Hodgkin lymphoma

Sophia S. Wang, Wendy Cozen, Richard K. Severson, Patricia Hartge, James R Cerhan, Scott Davis, Robert Welch, Nathaniel Rothman, Stephen J. Chanock

Research output: Contribution to journalArticle

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Abstract

To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (ORAA = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalHuman Genetics
Volume120
Issue number2
DOIs
StatePublished - Sep 2006

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Cyclin D1
Non-Hodgkin's Lymphoma
Confidence Intervals
cdc Genes
Population Control
B-Lymphocytes
Odds Ratio
Genes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Wang, S. S., Cozen, W., Severson, R. K., Hartge, P., Cerhan, J. R., Davis, S., ... Chanock, S. J. (2006). Cyclin D1 splice variant and risk for non-Hodgkin lymphoma. Human Genetics, 120(2), 297-300. https://doi.org/10.1007/s00439-006-0212-3

Cyclin D1 splice variant and risk for non-Hodgkin lymphoma. / Wang, Sophia S.; Cozen, Wendy; Severson, Richard K.; Hartge, Patricia; Cerhan, James R; Davis, Scott; Welch, Robert; Rothman, Nathaniel; Chanock, Stephen J.

In: Human Genetics, Vol. 120, No. 2, 09.2006, p. 297-300.

Research output: Contribution to journalArticle

Wang, SS, Cozen, W, Severson, RK, Hartge, P, Cerhan, JR, Davis, S, Welch, R, Rothman, N & Chanock, SJ 2006, 'Cyclin D1 splice variant and risk for non-Hodgkin lymphoma', Human Genetics, vol. 120, no. 2, pp. 297-300. https://doi.org/10.1007/s00439-006-0212-3
Wang SS, Cozen W, Severson RK, Hartge P, Cerhan JR, Davis S et al. Cyclin D1 splice variant and risk for non-Hodgkin lymphoma. Human Genetics. 2006 Sep;120(2):297-300. https://doi.org/10.1007/s00439-006-0212-3
Wang, Sophia S. ; Cozen, Wendy ; Severson, Richard K. ; Hartge, Patricia ; Cerhan, James R ; Davis, Scott ; Welch, Robert ; Rothman, Nathaniel ; Chanock, Stephen J. / Cyclin D1 splice variant and risk for non-Hodgkin lymphoma. In: Human Genetics. 2006 ; Vol. 120, No. 2. pp. 297-300.
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