Cyclin D1 expression in peripheral T-cell lymphomas

Joo Y. Song, Liping Song, Alex F. Herrera, Girish Venkataraman, Joyce L. Murata-Collins, Victoria H. Bedell, Yuan Yuan Chen, Young S. Kim, Reda Tadros, Bharat N. Nathwani, Dennis D. Weisenburger, Andrew L Feldman

Research output: Contribution to journalArticle

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Abstract

Cyclin D1 is an important regulator of the cell cycle and overexpression of this protein by immunohistochemistry is characteristically seen in mantle cell lymphoma and other B-cell neoplasms. However, little is known about the expression of this protein in T-cell lymphomas. Cyclin-dependent kinase pathway inhibitors are in development, therefore identifying cyclin D1-positive T-cell lymphomas may provide a therapeutic target in a disease where novel treatments are urgently needed. We collected 200 peripheral T-cell lymphomas from three institutions including the following types of cases: 34 anaplastic large cell lymphoma, ALK+, 44 anaplastic large cell lymphoma, ALK negative, 68 peripheral T-cell lymphomas, not otherwise specified, 24 angioimmunoblastic T-cell lymphomas, 7 extranodal NK/T-cell lymphomas, 4 enteropathy associated T-cell lymphomas, 3 hepatosplenic T-cell lymphomas, 12 cutaneous T-cell lymphomas, and 4 large granular lymphocytic leukemias. Immunohistochemical stains for cyclin D1 protein (SP4 clone) were performed on paraffin-embedded tissue. In a subset of cases, IGH/CCND1 fluorescence in situ hybridization analysis was also performed. Cyclin D1 staining was predominantly seen in anaplastic large cell lymphoma, including 8 of 34 cases with ALK+ anaplastic large cell lymphoma (24%), and 3 of 44 cases of ALK-negative (7%) anaplastic large cell lymphoma. Three cases of peripheral T-cell lymphoma, not otherwise specified, were also positive (3/68, 4%). All other T-cell lymphomas were negative for cyclin D1. In four of the cyclin D1-positive T-cell lymphomas by immunohistochemistry, fluorescence in situ hybridization analysis was negative for IGH/CCND1 translocation or extra copies of the CCND1 gene. Cyclin D1 overexpression by immunohistochemistry is not limited to B-cell lymphomas and is also observed in some peripheral T-cell lymphomas, particularly in anaplastic large cell lymphoma, ALK+. Cyclin D1 expression was not associated with extra copies or translocation of the CCND1 gene. Cyclin D1 overexpression may be the result of a post-translational phenomenon and may represent a potential therapeutic target using agents that target the cyclin-dependent kinase pathway.Modern Pathology advance online publication, 29 July 2016; doi:10.1038/modpathol.2016.136.

Original languageEnglish (US)
JournalModern Pathology
DOIs
StateAccepted/In press - Jul 29 2016

Fingerprint

Peripheral T-Cell Lymphoma
Cyclin D1
Anaplastic Large-Cell Lymphoma
T-Cell Lymphoma
Cyclin-Dependent Kinases
Immunohistochemistry
Fluorescence In Situ Hybridization
Extranodal NK-T-Cell Lymphoma
Enteropathy-Associated T-Cell Lymphoma
Large Granular Lymphocytic Leukemia
Mantle-Cell Lymphoma
Cutaneous T-Cell Lymphoma
Cell Cycle Proteins
B-Cell Lymphoma
Paraffin
Genes
Publications
Proteins
B-Lymphocytes
Coloring Agents

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Song, J. Y., Song, L., Herrera, A. F., Venkataraman, G., Murata-Collins, J. L., Bedell, V. H., ... Feldman, A. L. (Accepted/In press). Cyclin D1 expression in peripheral T-cell lymphomas. Modern Pathology. https://doi.org/10.1038/modpathol.2016.136

Cyclin D1 expression in peripheral T-cell lymphomas. / Song, Joo Y.; Song, Liping; Herrera, Alex F.; Venkataraman, Girish; Murata-Collins, Joyce L.; Bedell, Victoria H.; Chen, Yuan Yuan; Kim, Young S.; Tadros, Reda; Nathwani, Bharat N.; Weisenburger, Dennis D.; Feldman, Andrew L.

In: Modern Pathology, 29.07.2016.

Research output: Contribution to journalArticle

Song, JY, Song, L, Herrera, AF, Venkataraman, G, Murata-Collins, JL, Bedell, VH, Chen, YY, Kim, YS, Tadros, R, Nathwani, BN, Weisenburger, DD & Feldman, AL 2016, 'Cyclin D1 expression in peripheral T-cell lymphomas', Modern Pathology. https://doi.org/10.1038/modpathol.2016.136
Song JY, Song L, Herrera AF, Venkataraman G, Murata-Collins JL, Bedell VH et al. Cyclin D1 expression in peripheral T-cell lymphomas. Modern Pathology. 2016 Jul 29. https://doi.org/10.1038/modpathol.2016.136
Song, Joo Y. ; Song, Liping ; Herrera, Alex F. ; Venkataraman, Girish ; Murata-Collins, Joyce L. ; Bedell, Victoria H. ; Chen, Yuan Yuan ; Kim, Young S. ; Tadros, Reda ; Nathwani, Bharat N. ; Weisenburger, Dennis D. ; Feldman, Andrew L. / Cyclin D1 expression in peripheral T-cell lymphomas. In: Modern Pathology. 2016.
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