CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak

Kimberly N. Kremer; Kevin L. Peterson; Paula A. Schneider; X. Wei Meng; Haiming Dai; Allan D. Hess; B. Douglas Smith; Christie Rodriguez-Ramirez; Judith E. Karp; Scott H. Kaufmann; Karen E. Hedin

doi:10.1074/jbc.M113.449926

CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak

Kimberly N. Kremer, Kevin L. Peterson, Paula A. Schneider, X. Wei Meng, Haiming Dai, Allan D. Hess, B. Douglas Smith, Christie Rodriguez-Ramirez, Judith E. Karp, Scott H. Kaufmann, Karen E. Hedin

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Background: The chemokine receptor CXCR4 plays a role in AML. Results: SDF-1, the ligand of CXCR4, induces apoptosis in AML cell lines and patient samples via modulation of Bcl-2 family members. Conclusion: SDF-1 induces apoptosis of AML cells via up-regulation of Bak and Noxa and down-regulation of Bcl-XL. Significance: SDF-1/CXCR4 signaling could induce AML cell apoptosis if bone marrow survival cues can be disrupted.

Original language	English (US)
Pages (from-to)	22899-22914
Number of pages	16
Journal	Journal of Biological Chemistry
Volume	288
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M113.449926
State	Published - Aug 9 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Kremer, K. N., Peterson, K. L., Schneider, P. A., Meng, X. W., Dai, H., Hess, A. D., Smith, B. D., Rodriguez-Ramirez, C., Karp, J. E., Kaufmann, S. H., & Hedin, K. E. (2013). CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak. Journal of Biological Chemistry, 288(32), 22899-22914. https://doi.org/10.1074/jbc.M113.449926

CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak. / Kremer, Kimberly N.; Peterson, Kevin L.; Schneider, Paula A. et al.
In: Journal of Biological Chemistry, Vol. 288, No. 32, 09.08.2013, p. 22899-22914.

Research output: Contribution to journal › Article › peer-review

Kremer, KN, Peterson, KL, Schneider, PA, Meng, XW, Dai, H, Hess, AD, Smith, BD, Rodriguez-Ramirez, C, Karp, JE, Kaufmann, SH & Hedin, KE 2013, 'CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak', Journal of Biological Chemistry, vol. 288, no. 32, pp. 22899-22914. https://doi.org/10.1074/jbc.M113.449926

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title = "CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak",

abstract = "Background: The chemokine receptor CXCR4 plays a role in AML. Results: SDF-1, the ligand of CXCR4, induces apoptosis in AML cell lines and patient samples via modulation of Bcl-2 family members. Conclusion: SDF-1 induces apoptosis of AML cells via up-regulation of Bak and Noxa and down-regulation of Bcl-XL. Significance: SDF-1/CXCR4 signaling could induce AML cell apoptosis if bone marrow survival cues can be disrupted.",

author = "Kremer, {Kimberly N.} and Peterson, {Kevin L.} and Schneider, {Paula A.} and Meng, {X. Wei} and Haiming Dai and Hess, {Allan D.} and Smith, {B. Douglas} and Christie Rodriguez-Ramirez and Karp, {Judith E.} and Kaufmann, {Scott H.} and Hedin, {Karen E.}",

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doi = "10.1074/jbc.M113.449926",

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AU - Kremer, Kimberly N.

AU - Peterson, Kevin L.

AU - Schneider, Paula A.

AU - Meng, X. Wei

AU - Dai, Haiming

AU - Hess, Allan D.

AU - Smith, B. Douglas

AU - Rodriguez-Ramirez, Christie

AU - Karp, Judith E.

AU - Kaufmann, Scott H.

AU - Hedin, Karen E.

PY - 2013/8/9

Y1 - 2013/8/9

N2 - Background: The chemokine receptor CXCR4 plays a role in AML. Results: SDF-1, the ligand of CXCR4, induces apoptosis in AML cell lines and patient samples via modulation of Bcl-2 family members. Conclusion: SDF-1 induces apoptosis of AML cells via up-regulation of Bak and Noxa and down-regulation of Bcl-XL. Significance: SDF-1/CXCR4 signaling could induce AML cell apoptosis if bone marrow survival cues can be disrupted.

AB - Background: The chemokine receptor CXCR4 plays a role in AML. Results: SDF-1, the ligand of CXCR4, induces apoptosis in AML cell lines and patient samples via modulation of Bcl-2 family members. Conclusion: SDF-1 induces apoptosis of AML cells via up-regulation of Bak and Noxa and down-regulation of Bcl-XL. Significance: SDF-1/CXCR4 signaling could induce AML cell apoptosis if bone marrow survival cues can be disrupted.

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CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak

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