CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak

Kimberly N. Kremer, Kevin L. Peterson, Paula A. Schneider, X. Wei Meng, Haiming Dai, Allan D. Hess, B. Douglas Smith, Christie Rodriguez-Ramirez, Judith E. Karp, Scott H. Kaufmann, Karen E. Hedin

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Background: The chemokine receptor CXCR4 plays a role in AML. Results: SDF-1, the ligand of CXCR4, induces apoptosis in AML cell lines and patient samples via modulation of Bcl-2 family members. Conclusion: SDF-1 induces apoptosis of AML cells via up-regulation of Bak and Noxa and down-regulation of Bcl-XL. Significance: SDF-1/CXCR4 signaling could induce AML cell apoptosis if bone marrow survival cues can be disrupted.

Original languageEnglish (US)
Pages (from-to)22899-22914
Number of pages16
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Kremer, K. N., Peterson, K. L., Schneider, P. A., Meng, X. W., Dai, H., Hess, A. D., Smith, B. D., Rodriguez-Ramirez, C., Karp, J. E., Kaufmann, S. H., & Hedin, K. E. (2013). CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak. Journal of Biological Chemistry, 288(32), 22899-22914. https://doi.org/10.1074/jbc.M113.449926