CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak

Kimberly N. Kremer, Kevin L. Peterson, Paula A. Schneider, X. Wei Meng, Haiming Dai, Allan D. Hess, B. Douglas Smith, Christie Rodriguez-Ramirez, Judith E. Karp, Scott H Kaufmann, Karen Elaine Hedin

Research output: Contribution to journalArticle

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Abstract

Background: The chemokine receptor CXCR4 plays a role in AML. Results: SDF-1, the ligand of CXCR4, induces apoptosis in AML cell lines and patient samples via modulation of Bcl-2 family members. Conclusion: SDF-1 induces apoptosis of AML cells via up-regulation of Bak and Noxa and down-regulation of Bcl-XL. Significance: SDF-1/CXCR4 signaling could induce AML cell apoptosis if bone marrow survival cues can be disrupted.

Original languageEnglish (US)
Pages (from-to)22899-22914
Number of pages16
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013

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Noxae
CXCR4 Receptors
Chemokine Receptors
Myeloid Cells
Acute Myeloid Leukemia
Apoptosis
Bone Marrow Cells
Cues
Bone
Up-Regulation
Down-Regulation
Cells
Modulation
Ligands
Cell Line

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak. / Kremer, Kimberly N.; Peterson, Kevin L.; Schneider, Paula A.; Meng, X. Wei; Dai, Haiming; Hess, Allan D.; Smith, B. Douglas; Rodriguez-Ramirez, Christie; Karp, Judith E.; Kaufmann, Scott H; Hedin, Karen Elaine.

In: Journal of Biological Chemistry, Vol. 288, No. 32, 09.08.2013, p. 22899-22914.

Research output: Contribution to journalArticle

Kremer, Kimberly N. ; Peterson, Kevin L. ; Schneider, Paula A. ; Meng, X. Wei ; Dai, Haiming ; Hess, Allan D. ; Smith, B. Douglas ; Rodriguez-Ramirez, Christie ; Karp, Judith E. ; Kaufmann, Scott H ; Hedin, Karen Elaine. / CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 32. pp. 22899-22914.
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abstract = "Background: The chemokine receptor CXCR4 plays a role in AML. Results: SDF-1, the ligand of CXCR4, induces apoptosis in AML cell lines and patient samples via modulation of Bcl-2 family members. Conclusion: SDF-1 induces apoptosis of AML cells via up-regulation of Bak and Noxa and down-regulation of Bcl-XL. Significance: SDF-1/CXCR4 signaling could induce AML cell apoptosis if bone marrow survival cues can be disrupted.",
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AU - Schneider, Paula A.

AU - Meng, X. Wei

AU - Dai, Haiming

AU - Hess, Allan D.

AU - Smith, B. Douglas

AU - Rodriguez-Ramirez, Christie

AU - Karp, Judith E.

AU - Kaufmann, Scott H

AU - Hedin, Karen Elaine

PY - 2013/8/9

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N2 - Background: The chemokine receptor CXCR4 plays a role in AML. Results: SDF-1, the ligand of CXCR4, induces apoptosis in AML cell lines and patient samples via modulation of Bcl-2 family members. Conclusion: SDF-1 induces apoptosis of AML cells via up-regulation of Bak and Noxa and down-regulation of Bcl-XL. Significance: SDF-1/CXCR4 signaling could induce AML cell apoptosis if bone marrow survival cues can be disrupted.

AB - Background: The chemokine receptor CXCR4 plays a role in AML. Results: SDF-1, the ligand of CXCR4, induces apoptosis in AML cell lines and patient samples via modulation of Bcl-2 family members. Conclusion: SDF-1 induces apoptosis of AML cells via up-regulation of Bak and Noxa and down-regulation of Bcl-XL. Significance: SDF-1/CXCR4 signaling could induce AML cell apoptosis if bone marrow survival cues can be disrupted.

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