Cutting edge: The SLAM family receptor Ly108 controls T cell and neutrophil functions

Duncan Howie, F. Stephen Laroux, Massimo Morra, Abhay R. Satoskar, Lucia E. Rosas, William A. Faubion, Aimee Julien, Svend Rietdijk, Anthony J. Coyle, Christopher Fraser, Cox Terhorst

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Ly108, a glycoprotein of the signaling lymphocytic activation molecule family of cell surface receptors expressed by T, B, NK, and APCs has been shown to have a role in NK cell cytotoxicity and T cell cytokine responses. In this study, we describe that CD4+ T cells from mice with a targeted disruption of exons 2 and 3 of Ly108 (Ly108ΔE2+3) produce significantly less IL-4 than wild-type CD4+ cells, as judged by in vitro assays and by in vivo responses to cutaneous infection with Leishmania mexicana. Surprisingly, neutrophil functions are controlled by Ly108. Ly108 ΔE2+3 mice are highly susceptible to infection with Salmonella typhimurium, bactericidal activity of Ly108ΔE2+3 neutrophils is defective, and their production of IL-6, IL-12, and TNF-α is increased. The aberrant bactericidal activity by Ly108ΔE2+3 neutrophils is a consequence of severely reduced production of reactive oxygen species following phagocytosis of bacteria. Thus, Ly108 serves as a regulator of both innate and adaptive immune responses.

Original languageEnglish (US)
Pages (from-to)5931-5935
Number of pages5
JournalJournal of Immunology
Volume174
Issue number10
DOIs
StatePublished - May 15 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Howie, D., Laroux, F. S., Morra, M., Satoskar, A. R., Rosas, L. E., Faubion, W. A., Julien, A., Rietdijk, S., Coyle, A. J., Fraser, C., & Terhorst, C. (2005). Cutting edge: The SLAM family receptor Ly108 controls T cell and neutrophil functions. Journal of Immunology, 174(10), 5931-5935. https://doi.org/10.4049/jimmunol.174.10.5931