Cutting edge: Selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT

Koji Tamada, Jian Ni, Gefeng Zhu, Michele Fiscella, Baiqin Teng, Jan Van Deursen, Lieping Chen

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Interactions of LIGHT and its receptors, herpesvirus entry mediator on T cells and lymphotoxin β receptor on stromal cells, are implicated in the regulation of lymphoid organogenesis, costimulation of T cells, and activation of dendritic cells. In this work we report that LIGHT-deficient mice had normal lymphoid organs with T cells and APCs that normally responded to Ag stimulation and normally stimulated T cells. Although the number of Vβ8+ T cells in naive LIGHT+/+ and LIGHT-/- mice was identical, Vβ8+CD8+ T cell proliferation in response to staphylococcal enterotoxin B was significantly lower in LIGHT-/- mice. Consistently, induction and cytokine secretion of CD8+ CTL to MHC class I-restricted peptide was also reduced in LIGHT-/- mice. However, the proliferative response of Vβ8+ CD4+ T cells to staphylococcal enterotoxin B was comparable in LIGHT-/- and LIGHT+/+ mice. Our results suggest that LIGHT is required for activation of normal CD8+ T cells but not CD4+ T cells.

Original languageEnglish (US)
Pages (from-to)4832-4835
Number of pages4
JournalJournal of Immunology
Volume168
Issue number10
StatePublished - May 15 2002

Fingerprint

T-Lymphocytes
Light
Receptors, Tumor Necrosis Factor, Member 14
Lymphotoxin-alpha
Organogenesis
Stromal Cells
T-Cell Antigen Receptor
Dendritic Cells
Cell Proliferation
Cytokines
Peptides

ASJC Scopus subject areas

  • Immunology

Cite this

Cutting edge : Selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT. / Tamada, Koji; Ni, Jian; Zhu, Gefeng; Fiscella, Michele; Teng, Baiqin; Van Deursen, Jan; Chen, Lieping.

In: Journal of Immunology, Vol. 168, No. 10, 15.05.2002, p. 4832-4835.

Research output: Contribution to journalArticle

Tamada, K, Ni, J, Zhu, G, Fiscella, M, Teng, B, Van Deursen, J & Chen, L 2002, 'Cutting edge: Selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT', Journal of Immunology, vol. 168, no. 10, pp. 4832-4835.
Tamada, Koji ; Ni, Jian ; Zhu, Gefeng ; Fiscella, Michele ; Teng, Baiqin ; Van Deursen, Jan ; Chen, Lieping. / Cutting edge : Selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT. In: Journal of Immunology. 2002 ; Vol. 168, No. 10. pp. 4832-4835.
@article{08131d27336b4d7fb203b3a3cf030602,
title = "Cutting edge: Selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT",
abstract = "Interactions of LIGHT and its receptors, herpesvirus entry mediator on T cells and lymphotoxin β receptor on stromal cells, are implicated in the regulation of lymphoid organogenesis, costimulation of T cells, and activation of dendritic cells. In this work we report that LIGHT-deficient mice had normal lymphoid organs with T cells and APCs that normally responded to Ag stimulation and normally stimulated T cells. Although the number of Vβ8+ T cells in naive LIGHT+/+ and LIGHT-/- mice was identical, Vβ8+CD8+ T cell proliferation in response to staphylococcal enterotoxin B was significantly lower in LIGHT-/- mice. Consistently, induction and cytokine secretion of CD8+ CTL to MHC class I-restricted peptide was also reduced in LIGHT-/- mice. However, the proliferative response of Vβ8+ CD4+ T cells to staphylococcal enterotoxin B was comparable in LIGHT-/- and LIGHT+/+ mice. Our results suggest that LIGHT is required for activation of normal CD8+ T cells but not CD4+ T cells.",
author = "Koji Tamada and Jian Ni and Gefeng Zhu and Michele Fiscella and Baiqin Teng and {Van Deursen}, Jan and Lieping Chen",
year = "2002",
month = "5",
day = "15",
language = "English (US)",
volume = "168",
pages = "4832--4835",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "10",

}

TY - JOUR

T1 - Cutting edge

T2 - Selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT

AU - Tamada, Koji

AU - Ni, Jian

AU - Zhu, Gefeng

AU - Fiscella, Michele

AU - Teng, Baiqin

AU - Van Deursen, Jan

AU - Chen, Lieping

PY - 2002/5/15

Y1 - 2002/5/15

N2 - Interactions of LIGHT and its receptors, herpesvirus entry mediator on T cells and lymphotoxin β receptor on stromal cells, are implicated in the regulation of lymphoid organogenesis, costimulation of T cells, and activation of dendritic cells. In this work we report that LIGHT-deficient mice had normal lymphoid organs with T cells and APCs that normally responded to Ag stimulation and normally stimulated T cells. Although the number of Vβ8+ T cells in naive LIGHT+/+ and LIGHT-/- mice was identical, Vβ8+CD8+ T cell proliferation in response to staphylococcal enterotoxin B was significantly lower in LIGHT-/- mice. Consistently, induction and cytokine secretion of CD8+ CTL to MHC class I-restricted peptide was also reduced in LIGHT-/- mice. However, the proliferative response of Vβ8+ CD4+ T cells to staphylococcal enterotoxin B was comparable in LIGHT-/- and LIGHT+/+ mice. Our results suggest that LIGHT is required for activation of normal CD8+ T cells but not CD4+ T cells.

AB - Interactions of LIGHT and its receptors, herpesvirus entry mediator on T cells and lymphotoxin β receptor on stromal cells, are implicated in the regulation of lymphoid organogenesis, costimulation of T cells, and activation of dendritic cells. In this work we report that LIGHT-deficient mice had normal lymphoid organs with T cells and APCs that normally responded to Ag stimulation and normally stimulated T cells. Although the number of Vβ8+ T cells in naive LIGHT+/+ and LIGHT-/- mice was identical, Vβ8+CD8+ T cell proliferation in response to staphylococcal enterotoxin B was significantly lower in LIGHT-/- mice. Consistently, induction and cytokine secretion of CD8+ CTL to MHC class I-restricted peptide was also reduced in LIGHT-/- mice. However, the proliferative response of Vβ8+ CD4+ T cells to staphylococcal enterotoxin B was comparable in LIGHT-/- and LIGHT+/+ mice. Our results suggest that LIGHT is required for activation of normal CD8+ T cells but not CD4+ T cells.

UR - http://www.scopus.com/inward/record.url?scp=0037094087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037094087&partnerID=8YFLogxK

M3 - Article

C2 - 11994431

AN - SCOPUS:0037094087

VL - 168

SP - 4832

EP - 4835

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 10

ER -