TY - JOUR
T1 - Cutting edge
T2 - Selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT
AU - Tamada, Koji
AU - Ni, Jian
AU - Zhu, Gefeng
AU - Fiscella, Michele
AU - Teng, Baiqin
AU - Van Deursen, Jan M.A.
AU - Chen, Lieping
PY - 2002/5/15
Y1 - 2002/5/15
N2 - Interactions of LIGHT and its receptors, herpesvirus entry mediator on T cells and lymphotoxin β receptor on stromal cells, are implicated in the regulation of lymphoid organogenesis, costimulation of T cells, and activation of dendritic cells. In this work we report that LIGHT-deficient mice had normal lymphoid organs with T cells and APCs that normally responded to Ag stimulation and normally stimulated T cells. Although the number of Vβ8+ T cells in naive LIGHT+/+ and LIGHT-/- mice was identical, Vβ8+CD8+ T cell proliferation in response to staphylococcal enterotoxin B was significantly lower in LIGHT-/- mice. Consistently, induction and cytokine secretion of CD8+ CTL to MHC class I-restricted peptide was also reduced in LIGHT-/- mice. However, the proliferative response of Vβ8+ CD4+ T cells to staphylococcal enterotoxin B was comparable in LIGHT-/- and LIGHT+/+ mice. Our results suggest that LIGHT is required for activation of normal CD8+ T cells but not CD4+ T cells.
AB - Interactions of LIGHT and its receptors, herpesvirus entry mediator on T cells and lymphotoxin β receptor on stromal cells, are implicated in the regulation of lymphoid organogenesis, costimulation of T cells, and activation of dendritic cells. In this work we report that LIGHT-deficient mice had normal lymphoid organs with T cells and APCs that normally responded to Ag stimulation and normally stimulated T cells. Although the number of Vβ8+ T cells in naive LIGHT+/+ and LIGHT-/- mice was identical, Vβ8+CD8+ T cell proliferation in response to staphylococcal enterotoxin B was significantly lower in LIGHT-/- mice. Consistently, induction and cytokine secretion of CD8+ CTL to MHC class I-restricted peptide was also reduced in LIGHT-/- mice. However, the proliferative response of Vβ8+ CD4+ T cells to staphylococcal enterotoxin B was comparable in LIGHT-/- and LIGHT+/+ mice. Our results suggest that LIGHT is required for activation of normal CD8+ T cells but not CD4+ T cells.
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U2 - 10.4049/jimmunol.168.10.4832
DO - 10.4049/jimmunol.168.10.4832
M3 - Article
C2 - 11994431
AN - SCOPUS:0037094087
SN - 0022-1767
VL - 168
SP - 4832
EP - 4835
JO - Journal of Immunology
JF - Journal of Immunology
IS - 10
ER -