Cutaneous porphyrias part II: Treatment strategies

Suzanne Tintle, Ali Alikhan, Mary E. Horner, Jennifer L. Hand, Dawn Marie R. Davis

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

The porphyrias are diverse in pathophysiology, clinical presentation, severity, and prognosis, presenting a diagnostic and therapeutic challenge. Although not easily curable, the dermatological manifestations of these diseases, photosensitivity and associated cutaneous pathology, can be effectively prevented and managed. Sun avoidance is essential, and patient education regarding the irreversibility of photocutaneous damage is a necessary corollary. Beyond preventative measures, the care of fragile, vulnerable skin, and pain management, each of the porphyrias has a limited number of unique additional therapeutic options. Many of the treatments have been published only in small case series or anecdotal reports and do not have well-understood nor proven mechanisms of action. This article presents a comprehensive review of available therapeutic options and long-term management recommendations for the cutaneous porphyrias.

Original languageEnglish (US)
Pages (from-to)3-24
Number of pages22
JournalInternational journal of dermatology
Volume53
Issue number1
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Dermatology

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