Cutaneous photoprotection using a hydroxyl radical scavenger in photodynamic therapy

Norman D. Hogikyan, Richard E Hayden, Patrick W. McLear

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) is emerging as an effective therapy for a variety of malignant diseases, including head and neck cancer. Prolonged cutaneous photosensitivity following therapy, however, remains the most significant side effect. The biochemical mechanism of this sensitivity, and indeed of the tumoricidal effect of PDT, is uncertain, but is believed to involve formation of singlet oxygen and possibly other oxygen-derived free radicals. This laboratory recently reported that a singlet oxygen scavenger, diphenylisobenzofuran (DPIBF), afforded cutaneous photoprotection to 67% of animals treated with PDT. Those results, the first from an in vivo study, supported the idea that singlet oxygen plays a significant role in PDT and its associated toxicity. They also, however, suggested that it is not the sole intermediate. The current study looks at the photoprotective effects of the hydroxyl radical scavenger dimethyl thiourea, alone and in conjunction with DPIBF. Our results strongly support a role for the hydroxyl radical in producing the cutaneous phototoxicity associated with PDT.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalAmerican Journal of Otolaryngology--Head and Neck Medicine and Surgery
Volume12
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Photochemotherapy
Hydroxyl Radical
Singlet Oxygen
Skin
Phototoxic Dermatitis
Thiourea
Head and Neck Neoplasms
Free Radicals
Oxygen
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Cutaneous photoprotection using a hydroxyl radical scavenger in photodynamic therapy. / Hogikyan, Norman D.; Hayden, Richard E; McLear, Patrick W.

In: American Journal of Otolaryngology--Head and Neck Medicine and Surgery, Vol. 12, No. 1, 1991, p. 1-5.

Research output: Contribution to journalArticle

@article{b23f39b9be22454dbf1eabd22f0157e9,
title = "Cutaneous photoprotection using a hydroxyl radical scavenger in photodynamic therapy",
abstract = "Photodynamic therapy (PDT) is emerging as an effective therapy for a variety of malignant diseases, including head and neck cancer. Prolonged cutaneous photosensitivity following therapy, however, remains the most significant side effect. The biochemical mechanism of this sensitivity, and indeed of the tumoricidal effect of PDT, is uncertain, but is believed to involve formation of singlet oxygen and possibly other oxygen-derived free radicals. This laboratory recently reported that a singlet oxygen scavenger, diphenylisobenzofuran (DPIBF), afforded cutaneous photoprotection to 67{\%} of animals treated with PDT. Those results, the first from an in vivo study, supported the idea that singlet oxygen plays a significant role in PDT and its associated toxicity. They also, however, suggested that it is not the sole intermediate. The current study looks at the photoprotective effects of the hydroxyl radical scavenger dimethyl thiourea, alone and in conjunction with DPIBF. Our results strongly support a role for the hydroxyl radical in producing the cutaneous phototoxicity associated with PDT.",
author = "Hogikyan, {Norman D.} and Hayden, {Richard E} and McLear, {Patrick W.}",
year = "1991",
doi = "10.1016/0196-0709(91)90066-O",
language = "English (US)",
volume = "12",
pages = "1--5",
journal = "American Journal of Otolaryngology - Head and Neck Medicine and Surgery",
issn = "0196-0709",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Cutaneous photoprotection using a hydroxyl radical scavenger in photodynamic therapy

AU - Hogikyan, Norman D.

AU - Hayden, Richard E

AU - McLear, Patrick W.

PY - 1991

Y1 - 1991

N2 - Photodynamic therapy (PDT) is emerging as an effective therapy for a variety of malignant diseases, including head and neck cancer. Prolonged cutaneous photosensitivity following therapy, however, remains the most significant side effect. The biochemical mechanism of this sensitivity, and indeed of the tumoricidal effect of PDT, is uncertain, but is believed to involve formation of singlet oxygen and possibly other oxygen-derived free radicals. This laboratory recently reported that a singlet oxygen scavenger, diphenylisobenzofuran (DPIBF), afforded cutaneous photoprotection to 67% of animals treated with PDT. Those results, the first from an in vivo study, supported the idea that singlet oxygen plays a significant role in PDT and its associated toxicity. They also, however, suggested that it is not the sole intermediate. The current study looks at the photoprotective effects of the hydroxyl radical scavenger dimethyl thiourea, alone and in conjunction with DPIBF. Our results strongly support a role for the hydroxyl radical in producing the cutaneous phototoxicity associated with PDT.

AB - Photodynamic therapy (PDT) is emerging as an effective therapy for a variety of malignant diseases, including head and neck cancer. Prolonged cutaneous photosensitivity following therapy, however, remains the most significant side effect. The biochemical mechanism of this sensitivity, and indeed of the tumoricidal effect of PDT, is uncertain, but is believed to involve formation of singlet oxygen and possibly other oxygen-derived free radicals. This laboratory recently reported that a singlet oxygen scavenger, diphenylisobenzofuran (DPIBF), afforded cutaneous photoprotection to 67% of animals treated with PDT. Those results, the first from an in vivo study, supported the idea that singlet oxygen plays a significant role in PDT and its associated toxicity. They also, however, suggested that it is not the sole intermediate. The current study looks at the photoprotective effects of the hydroxyl radical scavenger dimethyl thiourea, alone and in conjunction with DPIBF. Our results strongly support a role for the hydroxyl radical in producing the cutaneous phototoxicity associated with PDT.

UR - http://www.scopus.com/inward/record.url?scp=0026028141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026028141&partnerID=8YFLogxK

U2 - 10.1016/0196-0709(91)90066-O

DO - 10.1016/0196-0709(91)90066-O

M3 - Article

VL - 12

SP - 1

EP - 5

JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery

JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery

SN - 0196-0709

IS - 1

ER -