TY - JOUR
T1 - Cutaneous photoprotection using a hydroxyl radical scavenger in photodynamic therapy
AU - Hogikyan, Norman D.
AU - Hayden, Richard E.
AU - McLear, Patrick W.
N1 - Funding Information:
Received September 2, 1990, from the Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO. Accepted for publication October 29, 1990. Presented at the Research Forum of the AAO-HNS annual meeting, September 1990. Supported in part by NIH grant no. T32-NS07278-05. Address correspondence and reprint requests to Norman D. Hogikyan, MD, Department of dtolaryngology, Washington Universitv Medical School, 517 S Euclid, Box 8115, St Louis, MO 6311b. Copyright 0 1991 by W.B. Saunders Company 0196-0709/91/1201-0008$5.00/O
PY - 1991
Y1 - 1991
N2 - Photodynamic therapy (PDT) is emerging as an effective therapy for a variety of malignant diseases, including head and neck cancer. Prolonged cutaneous photosensitivity following therapy, however, remains the most significant side effect. The biochemical mechanism of this sensitivity, and indeed of the tumoricidal effect of PDT, is uncertain, but is believed to involve formation of singlet oxygen and possibly other oxygen-derived free radicals. This laboratory recently reported that a singlet oxygen scavenger, diphenylisobenzofuran (DPIBF), afforded cutaneous photoprotection to 67% of animals treated with PDT. Those results, the first from an in vivo study, supported the idea that singlet oxygen plays a significant role in PDT and its associated toxicity. They also, however, suggested that it is not the sole intermediate. The current study looks at the photoprotective effects of the hydroxyl radical scavenger dimethyl thiourea, alone and in conjunction with DPIBF. Our results strongly support a role for the hydroxyl radical in producing the cutaneous phototoxicity associated with PDT.
AB - Photodynamic therapy (PDT) is emerging as an effective therapy for a variety of malignant diseases, including head and neck cancer. Prolonged cutaneous photosensitivity following therapy, however, remains the most significant side effect. The biochemical mechanism of this sensitivity, and indeed of the tumoricidal effect of PDT, is uncertain, but is believed to involve formation of singlet oxygen and possibly other oxygen-derived free radicals. This laboratory recently reported that a singlet oxygen scavenger, diphenylisobenzofuran (DPIBF), afforded cutaneous photoprotection to 67% of animals treated with PDT. Those results, the first from an in vivo study, supported the idea that singlet oxygen plays a significant role in PDT and its associated toxicity. They also, however, suggested that it is not the sole intermediate. The current study looks at the photoprotective effects of the hydroxyl radical scavenger dimethyl thiourea, alone and in conjunction with DPIBF. Our results strongly support a role for the hydroxyl radical in producing the cutaneous phototoxicity associated with PDT.
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U2 - 10.1016/0196-0709(91)90066-O
DO - 10.1016/0196-0709(91)90066-O
M3 - Article
C2 - 1851398
AN - SCOPUS:0026028141
SN - 0196-0709
VL - 12
SP - 1
EP - 5
JO - American Journal of Otolaryngology--Head and Neck Medicine and Surgery
JF - American Journal of Otolaryngology--Head and Neck Medicine and Surgery
IS - 1
ER -