Cutaneous lesions of angioimmunoblastic T-cell lymphoma: Clinical, pathological, and immunophenotypic features

Naoki Oishi, Julio Sartori Valinotti, Nabila Bennani, David A. Wada, Rong He, Mark A. Cappel, Andrew L Feldman

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Angioimmunoblastic T-cell lymphoma (AITL) is a systemic peripheral T-cell lymphoma with a follicular helper T-cell (T FH ) immunophenotype that frequently involves the skin. However, the histopathology of cutaneous involvement by AITL has not been fully established. Methods: We reviewed the clinicopathological features of 19 patients seen at our institution with AITL involving the skin. Pan-T-cell and T FH marker expression was evaluated by immunohistochemistry. Epstein-Barr virus (EBV) was detected using in situ hybridization (ISH) for Epstein-Barr virus-encoded small RNA (EBER). T-cell receptor (TCR) gene rearrangement was evaluated by PCR. Results: AITL affected both trunk and extremities in 15/19 cases (79%). Perivascular infiltration by small and/or medium-sized lymphocytes was seen in 18/19 (95%). Granulomatous inflammation was identified in 4/19 (21%). Aberrant loss of CD2, CD5, or CD7 was identified in 1/18 (6%), 2/18 (11%), or 7/19 (37%) cases, respectively. Seventeen of eighteen evaluable cases (95%) expressed 2 to 3 T FH markers: PD-1 in 19/19 (100%), BCL6 in 94% (17/18), and CD10 in 37% (7/19). EBV-positive cells were detected in 3/18 (17%) with varying density. Clonal TCR gene rearrangement was identified in 9/11 (82%). Conclusions: Cutaneous involvement by AITL shows relatively non-specific histopathological features. However, an immunohistochemical panel including T FH markers and EBER ISH is useful in differential diagnosis.

Original languageEnglish (US)
JournalJournal of Cutaneous Pathology
DOIs
StatePublished - Jan 1 2019

Keywords

  • angioimmunoblastic T-cell lymphoma
  • angioimmunoblastic T-cell lymphoma
  • cutaneous lymphoma
  • cutaneous lymphoma
  • Epstein-Barr virus
  • Epstein-Barr virus
  • follicular helper T-cell
  • follicular helper T-cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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