Cutaneous legionellosis: Case report and review of the medical literature

L. J. Padrnos, J. E. Blair, S. Kusne, D. J. Dicaudo, J. R. Mikhael

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Discrete nodules developed on the leg of a 27-year-old immunosuppressed woman after an allogeneic stem cell transplant. Biopsy and culture grew Legionella pneumophila serogroup 8. On day 7 of azithromycin treatment, respiratory distress and abnormal liver transaminases developed, and the patient died on day 14. Review of the medical literature identified 19 reports of Legionella species-associated skin or soft tissue infections (total of 20 patients, 13 with confirmed infection). Manifestations of the 13 confirmed cases included erythematous macular rash (n = 7), erythema after thoracentesis (n = 1), abscess formation (n = 4), respiratory symptoms (n = 6), and abnormal chest radiographs (n = 8). Six required surgical exploration and débridement, and 7 were immunocompromised. Rash and respiratory infection improved with antibiotics in 10, but 3 died. Immunosuppression may predispose transplant recipients to Legionella infections. Diagnostic biopsies may facilitate appropriate treatment.

Original languageEnglish (US)
Pages (from-to)307-314
Number of pages8
JournalTransplant Infectious Disease
Issue number2
StatePublished - Apr 2014


  • Cutaneous infection
  • Legionella
  • Legionella pneumophila
  • Legionellosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation


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