Cutaneous B-cell lymphoma with histologic features of mycosis fungoides

Sarah Chiang, David J. DiCaudo, Riccardo Valdez, David L. Swanson

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Histologic examination of skin biopsy specimens from a 57-year-old man with a pruritic rash on his chest, abdomen, and thighs revealed a dense atypical dermal lymphoid infiltrate bordering the dermoepidermal junction and scattered intraepithelial lymphocytes. Histopathologic and clinical features were suggestive of mycosis fungoides. Immunophenotyping studies, however, identified CD20+ B lymphocytes with aberrant expression of CD43. Clonal immunoglobulin gene rearrangement was demonstrated, and no clonal T-cell gene rearrangement was identified. Morphologic and immunophenotypic features were most consistent with extranodal marginal zone B-cell lymphoma. Systemic evaluation identified involvement of the bone marrow and possibly the peripheral blood, spleen, and splenic lymph nodes. Cutaneous manifestations were treated with narrowband ultraviolet B phototherapy for 3 months, resulting in complete resolution of the pruritus and rash. Primary and secondary cutaneous B-cell lymphomas seldom mimic mycosis fungoides histologically. Immunophenotyping studies were critical in correctly classifying this rare example of an epidermotropic B-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)320-323
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume62
Issue number2
DOIs
StatePublished - Feb 1 2010

Keywords

  • lymphoid tissue
  • phototherapy
  • pruritus

ASJC Scopus subject areas

  • Dermatology

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