Cushing's syndrome due to primary multinodular corticotrope hyperplasia

William Francis Young, B. W. Scheithauer, H. Gharib, E. R. Laws, P. C. Carpenter

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

In this report, a case of Cushing's syndrome due to primary multinodular corticotrope hyperplasia is described. The patient had typical features of Cushing's syndrome and dynamic pituitary-adrenal testing, which suggested an ectopic adrenocorticotropic hormone (ACTH) syndrome. Results of petrosal sinus catheterization indicated that the pituitary gland was the source of excess ACTH. Total hypophysectomy resulted in complete remission of Cushing's syndrome. Light microscopic and immunohistochemical studies revealed multinodular corticotrope hyperplasia. Plasma corticotropin releasing hormone (CRH) was undetectable, and computed tomography of the chest and abdomen disclosed no neoplastic source of CRH. We speculate that either an abnormality in hypothalamic CRH secretion or corticotrope hypersensitivity to CRH might have been responsible for Cushing's syndrome in this patient.

Original languageEnglish (US)
Pages (from-to)256-262
Number of pages7
JournalMayo Clinic Proceedings
Volume63
Issue number3
StatePublished - 1988

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Young, W. F., Scheithauer, B. W., Gharib, H., Laws, E. R., & Carpenter, P. C. (1988). Cushing's syndrome due to primary multinodular corticotrope hyperplasia. Mayo Clinic Proceedings, 63(3), 256-262.