TY - JOUR
T1 - Current status of outcome measures in vasculitis
T2 - Focus on Wegener's granulomatosis and microscopic polyangiitis. Report from OMERACT 7
AU - Merkel, Peter A.
AU - Seo, Philip
AU - Aries, Peter
AU - Neogi, Tuhina
AU - Villa-Forte, Alexandra
AU - Boers, Maarten
AU - Cuthbertson, David
AU - Felson, David T.
AU - Hellmich, Bernhard
AU - Hoffman, Gary S.
AU - Jayne, David R.
AU - Kallenberg, Cees G.M.
AU - Krischer, Jeffrey
AU - Mahr, Alfred
AU - Matteson, Eric L.
AU - Specks, Ulrich
AU - Luqmani, Raashid
AU - Stone, John H.
PY - 2005/12
Y1 - 2005/12
N2 - The complexity of assessing disease activity, disease status, and damage in the vasculitides reflects the multisystemic pathologic manifestations of these often chronic illnesses. Major progress has been made in the past decade in the development of validated and widely accepted outcome measures for use in clinical trials. Over time, these tools have been regularly revised, expanded, and supplemented with new measures of disease prognosis and damage. As a result clinical research in this area has become increasingly complex. This article critically reviews the current status of tools for assessing disease activity and damage in "ANCA-associated" vasculitides (Wegener's granulomatosis and microscopic polyangiitis), summarizes the current level of validation of each measure, addresses central problems and controversies to be considered during development of new vasculitis assessment tools, and proposes a series of research agendas for consideration by the vasculitis research community.
AB - The complexity of assessing disease activity, disease status, and damage in the vasculitides reflects the multisystemic pathologic manifestations of these often chronic illnesses. Major progress has been made in the past decade in the development of validated and widely accepted outcome measures for use in clinical trials. Over time, these tools have been regularly revised, expanded, and supplemented with new measures of disease prognosis and damage. As a result clinical research in this area has become increasingly complex. This article critically reviews the current status of tools for assessing disease activity and damage in "ANCA-associated" vasculitides (Wegener's granulomatosis and microscopic polyangiitis), summarizes the current level of validation of each measure, addresses central problems and controversies to be considered during development of new vasculitis assessment tools, and proposes a series of research agendas for consideration by the vasculitis research community.
KW - Microscopic polyangiitis
KW - Outcome measures
KW - Vasculitis
KW - Wegener's granulomatosis
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M3 - Article
C2 - 16331794
AN - SCOPUS:23644432864
SN - 0315-162X
VL - 32
SP - 2488
EP - 2495
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 12
ER -