Current status of outcome measures in vasculitis: Focus on Wegener's granulomatosis and microscopic polyangiitis. Report from OMERACT 7

Peter A. Merkel, Philip Seo, Peter Aries, Tuhina Neogi, Alexandra Villa-Forte, Maarten Boers, David Cuthbertson, David T. Felson, Bernhard Hellmich, Gary S. Hoffman, David R. Jayne, Cees G.M. Kallenberg, Jeffrey Krischer, Alfred Mahr, Eric L. Matteson, Ulrich Specks, Raashid Luqmani, John H. Stone

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The complexity of assessing disease activity, disease status, and damage in the vasculitides reflects the multisystemic pathologic manifestations of these often chronic illnesses. Major progress has been made in the past decade in the development of validated and widely accepted outcome measures for use in clinical trials. Over time, these tools have been regularly revised, expanded, and supplemented with new measures of disease prognosis and damage. As a result clinical research in this area has become increasingly complex. This article critically reviews the current status of tools for assessing disease activity and damage in "ANCA-associated" vasculitides (Wegener's granulomatosis and microscopic polyangiitis), summarizes the current level of validation of each measure, addresses central problems and controversies to be considered during development of new vasculitis assessment tools, and proposes a series of research agendas for consideration by the vasculitis research community.

Original languageEnglish (US)
Pages (from-to)2488-2495
Number of pages8
JournalJournal of Rheumatology
Volume32
Issue number12
StatePublished - Dec 2005

Keywords

  • Microscopic polyangiitis
  • Outcome measures
  • Vasculitis
  • Wegener's granulomatosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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