Current Status of Liver Transplantation for Primary Biliary Cholangitis

Maria T. Aguilar, Elizabeth J. Carey

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease diagnosed with elevated alkaline phosphatase in the presence of antimitochondrial antibody. With the introduction and widespread use of ursodeoxycholic acid the proportion of PBC patients undergoing liver transplant (LT) has decreased. However, up to 40% of patients are ursodeoxycholic acid nonresponders and require second-line treatment or progress to end-stage liver disease requiring LT. Several scoring systems have been developed and validated to assess treatment response and transplant-free survival in patients. Although PBC is a favorable indication for LT, recurrence of PBC may occur and requires biopsy for diagnosis.

Original languageEnglish (US)
Pages (from-to)613-624
Number of pages12
JournalClinics in Liver Disease
Volume22
Issue number3
DOIs
StatePublished - Aug 1 2018

Keywords

  • GLOBE score
  • Liver transplant
  • Mayo Risk Score
  • Obeticholic acid
  • Primary biliary cholangitis
  • Recurrent PBC
  • UK-PBC
  • Ursodeoxycholic acid

ASJC Scopus subject areas

  • Hepatology

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