Abstract
PURPOSE OF REVIEW: Tumor growth elicits antigen-specific cytotoxic as well as immune suppressive responses. Interleukin-10 (IL-10) is a key immune-suppressive cytokine produced by regulatory T-cells and by helper T-cells. Here, we review pleiotropic functions of IL-10 that impact the immune pathology of cancer. RECENT FINDINGS: The role of IL-10 in cancer has become less certain with the knowledge of its immune stimulatory functions. IL-10 is needed for T-helper cell functions, T-cell immune surveillance, and suppression of cancer-associated inflammation. By promoting tumor-specific immune surveillance and hindering pathogenic inflammation, IL-10 is emerging as a key cytokine in the battle of the host against cancer. SUMMARY: IL-10 functions at the cross-roads of immune stimulation and immune suppression in cancer. Immunological mechanisms of action of IL-10 can be ultimately exploited to develop novel and effective cancer therapies.
Original language | English (US) |
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Pages (from-to) | 637-645 |
Number of pages | 9 |
Journal | Current Opinion in Oncology |
Volume | 25 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2013 |
Keywords
- cancer
- immune surveillance
- inflammation
- interleukin-10
- tregs
ASJC Scopus subject areas
- Oncology
- Cancer Research