Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity

Theodore J. Kottom; Eva M. Carmona; Andrew H. Limper

doi:10.3389/fimmu.2021.798214

Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity

Theodore J. Kottom, Eva M. Carmona, Andrew H. Limper

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism’s cell wall components including β-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/Pneumocystis interactions.

Original language	English (US)
Article number	798214
Journal	Frontiers in immunology
Volume	12
DOIs	https://doi.org/10.3389/fimmu.2021.798214
State	Published - Dec 16 2021

Keywords

CLR
Pneumocystis
beta-glucans
inflammation
pneumonia

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3389/fimmu.2021.798214

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title = "Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity",

abstract = "Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism{\textquoteright}s cell wall components including β-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/Pneumocystis interactions.",

keywords = "CLR, Pneumocystis, beta-glucans, inflammation, pneumonia",

author = "Kottom, {Theodore J.} and Carmona, {Eva M.} and Limper, {Andrew H.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 Kottom, Carmona and Limper.",

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doi = "10.3389/fimmu.2021.798214",

language = "English (US)",

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AU - Carmona, Eva M.

AU - Limper, Andrew H.

PY - 2021/12/16

Y1 - 2021/12/16

N2 - Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism’s cell wall components including β-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/Pneumocystis interactions.

AB - Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism’s cell wall components including β-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/Pneumocystis interactions.

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KW - Pneumocystis

KW - beta-glucans

KW - inflammation

KW - pneumonia

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AN - SCOPUS:85122075760

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JO - Frontiers in immunology

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Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity

Abstract

Keywords

ASJC Scopus subject areas

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