Current Opinions and Consensus for Studying Tremor in Animal Models

Sheng Han Kuo, Elan D. Louis, Phyllis L. Faust, Adrian Handforth, Su youne Chang, Billur Avlar, Eric J. Lang, Ming Kai Pan, Lauren N. Miterko, Amanda M. Brown, Roy V. Sillitoe, Collin J. Anderson, Stefan M. Pulst, Martin J. Gallagher, Kyle A. Lyman, Dane M. Chetkovich, Lorraine N. Clark, Murni Tio, Eng King Tan, Rodger J. Elble

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Tremor is the most common movement disorder; however, we are just beginning to understand the brain circuitry that generates tremor. Various neuroimaging, neuropathological, and physiological studies in human tremor disorders have been performed to further our knowledge of tremor. But, the causal relationship between these observations and tremor is usually difficult to establish and detailed mechanisms are not sufficiently studied. To overcome these obstacles, animal models can provide an important means to look into human tremor disorders. In this manuscript, we will discuss the use of different species of animals (mice, rats, fruit flies, pigs, and monkeys) to model human tremor disorders. Several ways to manipulate the brain circuitry and physiology in these animal models (pharmacology, genetics, and lesioning) will also be discussed. Finally, we will discuss how these animal models can help us to gain knowledge of the pathophysiology of human tremor disorders, which could serve as a platform towards developing novel therapies for tremor.

Original languageEnglish (US)
Pages (from-to)1036-1063
Number of pages28
JournalCerebellum
Volume18
Issue number6
DOIs
StatePublished - Dec 1 2019

Keywords

  • Animal models
  • Cerebellum
  • Genetics
  • Pathology
  • Physiology
  • Purkinje cells
  • Tremor

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Kuo, S. H., Louis, E. D., Faust, P. L., Handforth, A., Chang, S. Y., Avlar, B., Lang, E. J., Pan, M. K., Miterko, L. N., Brown, A. M., Sillitoe, R. V., Anderson, C. J., Pulst, S. M., Gallagher, M. J., Lyman, K. A., Chetkovich, D. M., Clark, L. N., Tio, M., Tan, E. K., & Elble, R. J. (2019). Current Opinions and Consensus for Studying Tremor in Animal Models. Cerebellum, 18(6), 1036-1063. https://doi.org/10.1007/s12311-019-01037-1